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Special Issue "102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 28 March 2024 | Viewed by 122

Special Issue Editor

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institute, 14183 Huddinge, Sweden
Interests: nerve growth factor; neurotrophins; Alzheimer’s disease; therapy; encapsulated cell biodelivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The discovery of chemical synaptic transmission by Otto Loewi in 1921, and the further identification of acetylcholine as the first chemical moiety by Sir Hallett Dale, paved the way for an early understanding of the role of chemical messengers (termed neurotransmitters) in neurotransmission. These findings led to further discoveries of other chemical neurotransmitters and provided a new outlook on neuromodulation, as well as enhanced knowledge about the intricate network of signalling partners and specific receptors that make each neurotransmitter system unique. Acetylcholine, the primary modulator of the parasympathetic nervous system, was specifically shown to modulate neuromuscular junctions, inflammatory processes, blood vessel dilation, and glandular secretions, amongst others. The modulation of acetylcholine levels has been associated with pathological conditions, which makes it a noteworthy neurotransmitter to study in the context of human health.

This Special Issue invites recent advances on the role of acetylcholine in various aspects of physiological or pathological conditions.

Dr. Sumonto Mitra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • acetylcholine
  • physiological functions
  • pathological alterations
  • cholinergic pathways

Published Papers

This special issue is now open for submission.
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