Special Issue "102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology"
Deadline for manuscript submissions: 28 March 2024 | Viewed by 122
Interests: nerve growth factor; neurotrophins; Alzheimer’s disease; therapy; encapsulated cell biodelivery
Special Issues, Collections and Topics in MDPI journals
The discovery of chemical synaptic transmission by Otto Loewi in 1921, and the further identification of acetylcholine as the first chemical moiety by Sir Hallett Dale, paved the way for an early understanding of the role of chemical messengers (termed neurotransmitters) in neurotransmission. These findings led to further discoveries of other chemical neurotransmitters and provided a new outlook on neuromodulation, as well as enhanced knowledge about the intricate network of signalling partners and specific receptors that make each neurotransmitter system unique. Acetylcholine, the primary modulator of the parasympathetic nervous system, was specifically shown to modulate neuromuscular junctions, inflammatory processes, blood vessel dilation, and glandular secretions, amongst others. The modulation of acetylcholine levels has been associated with pathological conditions, which makes it a noteworthy neurotransmitter to study in the context of human health.
This Special Issue invites recent advances on the role of acetylcholine in various aspects of physiological or pathological conditions.
Dr. Sumonto Mitra
Manuscript Submission Information
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- physiological functions
- pathological alterations
- cholinergic pathways