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Special Issue "New Molecular Therapeutic Approaches for Cystic Fibrosis"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 147

Special Issue Editors

Center on Advanced Studies and Technology (CAST), Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Interests: cystic fibrosis; CFTR modulation; inflammation
Laboratory of Experimental and Regenerative Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy
Interests: CFTR protein; CF genetics; personalized medicine; infection and inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lung disease represents the main cause of cystic fibrosis (CF) morbidity and mortality. In the bronchial epithelium, a dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR) causes the accumulation of dense mucus, chronic infection, and neutrophilic inflammation, which can lead to respiratory insufficiency and death. The advent of CFTR modulators has improved the quality of life of many people with CF. However, although F508-del is the most frequent mutation, effective therapy for most of disease-causing mutations identified in CF is not yet available. Moreover, recurrent pathogen infections reduce modulator efficacy and sustain a chronic inflammatory status still requiring treatment with antibacterial agents.

Molecular therapeutics have been developed in the recent years and they could be exploited in CF to correct mutations, to reduce inflammation and to develop antibacterial drugs.

A main problem in CF research is the need of adequate ex vivo and preclinical models, and the development of respiratory 3D structures, as organoids and lungs/airways-on-chip, has provided new tools for studying lung diseases, and could be suitable for new therapeutic approches in CF.

This Special Issue aims to be a call for original articles/reviews about molecular therapeutic approaches in CF regarding:

  • CFTR correction/modulation/overexpression;
  • Transfection of differentiated epithelia;
  • Pathogen infection/antibiotic resistance;
  • Techniques of drug delivery;
  • 3D models suitable for drug testing.

Dr. Roberto Plebani
Dr. Onofrio Laselva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cystic fibrosis
  • inflammation
  • 3D structures
  • organ-on-chip technology
  • organoids
  • endothelium
  • pulmonary disease
  • pathogens
  • drug resistance
  • miRNA
  • RNA interfering
  • CRISPR/Cas9
  • transfection
  • drug delivery

Published Papers

This special issue is now open for submission.
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