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Cannabis: Chemical Compositions and Molecular Pharmacology
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Cannabis: Chemical Compositions and Molecular Pharmacology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 11544

Special Issue Editor

Prof. Dr. William N. Setzer

grade E-Mail Website
Guest Editor
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA
Interests: natural product drug discovery; phytochemistry; essential oils; chemical ecology; molecular modeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cannabis has been used therapeutically for thousands of years. Although Cannabis was illegal in most of the world during the 20th century, it has recently seen a revival in medicinal applications, and legalization has served to increase its use in medicine. Cannabis has been noted for its sedative, anticonvulsant, and pain-relieving qualities, and its potential benefit for treating psychiatric disorders. The demand for Cannabis for medicinal use requires standardization: the chemical compositions of Cannabis can vary widely, and adulteration may be problematic. For this Special Issue, we invite original research and timely reviews on the chemical compositions of Cannabis, variations in composition, potential contaminants and adulterants, as well as the molecular aspects of pharmacology and toxicology.

Prof. William N. Setzer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

33 pages, 8059 KiB  
Review
Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products
by Dongchen An, Steve Peigneur, Louise Antonia Hendrickx and Jan Tytgat
Int. J. Mol. Sci. 2020, 21(14), 5064; https://doi.org/10.3390/ijms21145064 - 17 Jul 2020
Cited by 100 | Viewed by 10642
Abstract
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids [...] Read more.
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to develop ligands for CB1 and CB2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. However, only a few of these ligands are clinically used. Recently, more detailed structural information for cannabinoid receptors was revealed thanks to the powerfulness of cryo-electron microscopy, which now can accelerate structure-based drug discovery. At the same time, novel peptide-type cannabinoids from animal sources have arrived at the scene, with their potential in vivo therapeutic effects in relation to cannabinoid receptors. From a natural products perspective, it is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, including voltage- and ligand-gated ion channels, G protein-coupled receptors such as CB1 and CB2, with astonishing affinity and selectivity. Therefore, it is believed that discovering novel cannabinoids starting from studying the biodiversity of the species living on planet earth is an uncharted territory. Full article
(This article belongs to the Special Issue Cannabis: Chemical Compositions and Molecular Pharmacology)
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