Special Issue "Structure and Function of Ribosomal Proteins 2023"
Deadline for manuscript submissions: 15 February 2024 | Viewed by 1181
Interests: structure of the eukaryotic ribosome; regulation of translation in eukaryotes; eukaryotic ribosomal proteins: functions within the ribosome and extra-ribosomalfunctions; transport of ribosomal proteins by exosomes
The ribosome consists of two subunits, with each containing several dozens of ribosomal proteins (RPs). Most of them are critically important constituents of the subunits and contribute to their structures’ ability to carry out translations; some RPs directly participate in the formation of ribosomal functional sites. Deciphering the structures of translational ribosomal complexes at a near-atomic resolution using X-ray crystallography and cryo-electron microscopy revealed details of the arrangement of the functional sites and provided ideas regarding interactions between the RPs and translation participants (mRNA, tRNAs and translation factors). However, the contribution of particular RP regions, which have been suggested to contact ribosomal ligands, to the work of the ribosomal machinery (especially the eukaryotic one) has become clear only recently, following investigations into the effects that mutations in these regions have on the translational properties of the ribosomes. Many eukaryotic RPs have non-canonical functions that often have no direct relation to protein synthesis (“extra-ribosomal” funtions). The knowledge of the functional assignments of RPs and their particular regions is important for understanding the molecular mechanisms of translation; it is also considerably relevant to biomedicine, since numerous data have revealed various links between disturbances in translation and/or extra-ribosomal functions of RPs and particular diseases.
Dr. Dmitri Graifer
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- ribosomal proteins
- particular regions of ribosomal proteins
- translation and its regulation
- roles of particular ribosomal proteins’ regions in translation
- roles of particular ribosomal proteins’ regions in extra-ribosomal functions
- mutations in ribosomal proteins and human diseases