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Molecular Genetics of Human Diseases: Focus on Intestinal Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1183

Special Issue Editor


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Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Viale delle Scienze, Edificio 16, 90128 Palermo, Italy
Interests: nutrigenomics; epigenetics; gene expression; precision nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Environmental factors, such as nutrition, stress, chemicals, infections, and other factors, have been shown to play a significant role in the development of intestinal cancers. The link between diet and the risk of developing colorectal and other intestinal cancers has long been recognized, but the cellular and molecular mechanisms underlying this connection remain unclear.

Recent research has suggested that epigenetic modifications, including DNA methylation, post-transcriptional modifications of histone, and non-coding RNAs, may play a role in the development of these cancers. In particular, dietary compounds have been shown to influence epigenetic modifications, potentially affecting gene expression and contributing to cancer development. Stem cells in the gut, as well as the gut microbiome, have been identified as targets for further study in this context.

We invite submissions of original research articles, reviews, and meta-analyses that explore the links between dietary exposures, genetic and epigenetic changes, and the risk of intestinal cancers in adulthood. Our goal is to advance our understanding of the cellular and molecular mechanisms underlying the development of these cancers and to develop new strategies for their prevention and treatment.

We believe that this Special Issue will make a valuable contribution to the field and improve public health outcomes related to intestinal cancers. Thank you for your contributions.

Dr. Flores Naselli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intestinal cancer
  • dietary compound
  • nutrigenomics
  • DNA methylation
  • non-coding RNAs
  • histone modifications
  • epigenetic changes
  • gut microbiome
  • intestinal disease
  • environmental factors

Published Papers (1 paper)

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Review

14 pages, 985 KiB  
Review
Drought-Adapted Mediterranean Diet Plants: A Source of Bioactive Molecules Able to Give Nutrigenomic Effects per sè or to Obtain Functional Foods
by Silvia La Scala, Flores Naselli, Paola Quatrini, Giuseppe Gallo and Fabio Caradonna
Int. J. Mol. Sci. 2024, 25(4), 2235; https://doi.org/10.3390/ijms25042235 - 13 Feb 2024
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Abstract
The Mediterranean diet features plant-based foods renowned for their health benefits derived from bioactive compounds. This review aims to provide an overview of the bioactive molecules present in some representative Mediterranean diet plants, examining their human nutrigenomic effects and health benefits as well [...] Read more.
The Mediterranean diet features plant-based foods renowned for their health benefits derived from bioactive compounds. This review aims to provide an overview of the bioactive molecules present in some representative Mediterranean diet plants, examining their human nutrigenomic effects and health benefits as well as the environmental advantages and sustainability derived from their cultivation. Additionally, it explores the facilitation of producing fortified foods aided by soil and plant microbiota properties. Well-studied examples, such as extra virgin olive oil and citrus fruits, have demonstrated significant health advantages, including anti-cancer, anti-inflammatory, and neuroprotective effects. Other less renowned plants are presented in the scientific literature with their beneficial traits on human health highlighted. Prickly pear’s indicaxanthin exhibits antioxidant properties and potential anticancer traits, while capers kaempferol and quercetin support cardiovascular health and prevent cancer. Oregano and thyme, containing terpenoids like carvacrol and γ-terpinene, exhibit antimicrobial effects. Besides their nutrigenomic effects, these plants thrive in arid environments, offering benefits associated with their cultivation. Their microbiota, particularly Plant Growth Promoting (PGP) microorganisms, enhance plant growth and stress tolerance, offering biotechnological opportunities for sustainable agriculture. In conclusion, leveraging plant microbiota could revolutionize agricultural practices and increase sustainability as climate change threatens biodiversity. These edible plant species may have crucial importance, not only as healthy products but also for increasing the sustainability of agricultural systems. Full article
(This article belongs to the Special Issue Molecular Genetics of Human Diseases: Focus on Intestinal Cancers)
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