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Thyroid Hormone and Molecular Endocrinology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1930

Special Issue Editor


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Guest Editor
Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-220, Brazil
Interests: hormonal regulation; gene expression: thyroid hormone; therapeutic

Special Issue Information

Dear Colleagues, 

Thyroid hormone plays an important role in growth, development, tissue homeostasis, and metabolism. In recent years, thyroid hormones and analogues have shown significant therapeutic potential for metabolic diseases such as diabetes, obesity and dyslipidemia. To deepen the understanding of the molecular basis of thyroid hormone actions, this Special Issue titled “Thyroid Hormone and Molecular Endocrinology” aims to collect the latest original recent articles and reviews describing the molecular aspects of thyroid hormone, including but not limited to the following areas: 

  • Thyroid hormone;
  • Hormone regulation;
  • Thyroid gene expression;
  • Potential therapeutic application;
  • Hypothyroidism;
  • TH analogues;
  • Diabetes mellitus.

Prof. Dr. Maria Tereza Nunes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hormonal regulation
  • gene expression: thyroid hormone
  • therapeutic
  • thyroid hormone receptors
  • diabetes
  • obesity
  • hyperlipidemia
  • T3

Published Papers (1 paper)

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Research

11 pages, 1741 KiB  
Article
Ultrasound Parameters Can Accurately Predict the Risk of Malignancy in Patients with “Indeterminate TIR3b” Cytology Nodules: A Prospective Study
by Valentina Guarnotta, Roberta La Monica, Vincenza Rita Ingrao, Claudia Di Stefano, Riccardo Salzillo, Giuseppe Pizzolanti, Antonino Giulio Giannone, Piero Luigi Almasio, Pierina Richiusa and Carla Giordano
Int. J. Mol. Sci. 2023, 24(9), 8296; https://doi.org/10.3390/ijms24098296 - 5 May 2023
Viewed by 1203
Abstract
The increase in the incidence of thyroid nodules with cytological findings of TIR3b requires the identification of predictive factors of malignancy. We prospectively evaluated 2160 patients from January 2018 to June 2022 and enrolled 103 patients with indeterminate cytology TIR3b nodules who underwent [...] Read more.
The increase in the incidence of thyroid nodules with cytological findings of TIR3b requires the identification of predictive factors of malignancy. We prospectively evaluated 2160 patients from January 2018 to June 2022 and enrolled 103 patients with indeterminate cytology TIR3b nodules who underwent total (73 patients) and hemi-thyroidectomy (30 patients). Among them, 61 had a histological diagnosis of malignancy (30 classic papillary thyroid carcinoma, 19 had follicular papillary thyroid carcinoma variant, 3 had Hurtle cell carcinoma and 9 had follicular thyroid carcinoma), while 42 had a benign histology. Clinical, ultrasonographic and cytological characteristics were recorded. In addition, BRAF mutation was analysed. Patients with a histological diagnosis of malignancy had a higher frequency of nodule diameter ≤11 mm (p = 0.002), hypoechogenicity (p < 0.001), irregular borders (p < 0.001), peri- and intralesional vascular flows (p = 0.004) and microcalcifications (p = 0.001) compared to patients with benign histology. In contrast, patients with benign histology had more frequent nodules with a halo sign (p = 0.012) compared to patients with histological diagnosis of malignancy. No significant differences were found in BRAF mutation between the two groups. Our study suggests that the combination of ultrasonographic and cytological data could be more accurate and reliable than cytology alone in identifying those patients with TIR3b cytology and a histology of malignancy to be referred for thyroidectomy, thus reducing the number of patients undergoing thyroidectomy for benign thyroid disease. Full article
(This article belongs to the Special Issue Thyroid Hormone and Molecular Endocrinology)
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