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Molecular Mechanisms in the Etiology and Pathogenesis of Autoimmune Diabetes

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 123

Special Issue Editor


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Guest Editor
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Interests: type 1 diabetes; type 2 diabetes; obesity; beta cell biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Autoimmune diabetes, commonly referred to as type 1 diabetes mellitus (T1D), is a persistent immune-mediated condition marked by a lack of insulin due to the destruction of pancreatic beta cells, leading to elevated blood glucose levels. The cause of autoimmune diabetes remains unknown, but is believed to involve a combination of genetic and environmental factors. Genetic factors may play a minor role as only 15% of children with T1D have close relatives with T1D. As T1D is more abundant in developed countries (North America, Western Europe and Australia) than in developing countries, where infectious diseases are more common, it is suspected that a lack of stimulation of the immune system may increase the risk of autoimmune diseases like T1D, supporting the so-called “hygiene hypothesis”. Although the discovery of insulin in 1921 transformed T1D from an invariable fatal disease into a life-long chronic condition, people with T1D have a reduced life expectancy due to a risk of complications. Consequently, there is a great need to develop immune-based therapies and beta cell replacement strategies for its treatment.

This Special Issue aims to present readers with an up-to-date overview of ongoing molecular research addressing questions related to autoimmune diabetes physiopathology, ranging from its etiology and pathogenesis to therapeutic approaches. Both original research articles and comprehensive reviews of high educational value covering different aspects of autoimmune diabetes are welcome.

Prof. Dr. Jens Høiriis Nielsen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 1 diabetes
  • autoimmune diabetes
  • pathophysiology
  • pancreatic beta cell
  • immune therapies
  • beta cell replacement therapy
  • stem cell development

Published Papers

This special issue is now open for submission.
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