Special Issue "From Basic Radiobiology to Translational Radiotherapy"
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 19290
Interests: DNA damage; flavonoids; DNA repair; cytogenetics; radiobiology
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Special Issue in Genes: DNA and Chromosomal Lesions in Tumorigenesis
A major goal of radiotherapy is to control tumor mass with minimal effects on the surrounding normal tissues. To achieve this, basic radiation responses in normal and cancer cells need to be understood. In cell molecular biology, this includes DNA damage and repair, cell cycle effects, cell death, and genomic instability, including somatic mutations and epigenetic modifications. Cellular radiation responses are altered by oxygen concentrations, temperature, and other microenvironmental factors, as well as small molecules classified as radio-sensitizers and radio-protectors. Radiotherapy can be combined with other cancer treatment modalities such as chemotherapy and immunotherapy.
This Special Issue is focused on radiobiology research that can be translational to clinical radiotherapy. It includes topics from basic cell and molecular responses to radiation to clinical trials. This Special Issue will help basic radiation and cancer biology researchers as well as clinical radiation oncologists to update their knowledge for better radiotherapy.
Dr. Takamitsu Kato
Dr. Hiroto Yoshikawa
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- ionizing radiation
- DNA damage
- DNA repair
- chromosome aberrations
- cell death
- tumor microenvironment