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Molecular Advances in Obstetrical and Gynaecological Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 697

Special Issue Editor


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Guest Editor
2nd Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Interests: gynecology; obstetrics; reproductive; endocrinology; mullerian anomalies; PCOS; pediatric gynecology; high-risk pregnancy; adolescent gynecology; minimally invasive surgery
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Special Issue Information

Dear Colleagues,

Gynaecological disorders, ranging from developmental disorders to cancer, represent some of the most common health conditions in women that affect their health-related quality of life and life expectancy, both in reproductive age and after menopause. With regard to pregnancy, several disorders, such as diabetes and hypertension, frequently affect both the pregnant woman's and the offspring’s health, giving rise to negative intergenerational cycles.

Recent advances in molecular biology have shed light on the aetiology and pathophysiology of obstetrical and gynaecological complaints, which facilitated research in diagnosing and managing these disorders. For example, molecular research has indicated several biomarkers for the early diagnosis of cervical cancer, and micro-RNAs have been involved in the non-invasive diagnosis of endometriosis. In addition, recent research in genetics and epigenetics has enlightened causative pathways in developmental disorders, such as Mayer–Rokitansky–Küster–Hauser (MRKH) Syndrome. Furthermore, molecular techniques are applied in precision-medicine research regarding infertility and ovarian disorders, such as polycystic ovary syndrome (PCOS), anovulation, and premature ovarian failure.

This Special Issue on “Molecular Advances in Obstetrical and Gynaecological Disorders” aims to include clinical and basic science in the form of both original research and review papers, investigating obstetrical and gynaecological disorders with respect to molecular pathology, diagnostics, and therapeutics; molecular biology, oncology, and immunology; molecular genetics and genomics; molecular endocrinology and metabolism; and molecular informatics.

Dr. Panagiotis Christopoulos
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • female reproduction
  • infertility
  • embryo development
  • genealogical disorders
  • cancer
  • biomarkers
  • molecular therapy
  • epigenetics

Published Papers (1 paper)

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Research

13 pages, 1259 KiB  
Article
Arsenic Methyltransferase and Apolipoprotein E Polymorphism in Pregnant Women Exposed to Inorganic Arsenic in Drinking Water in Western Romania
by Laura Ancuta Pop, Ioana Berindan-Neagoe, Michael S. Bloom, Iulia Adina Neamtiu, Cecilia Bica and Eugen S. Gurzau
Int. J. Mol. Sci. 2024, 25(6), 3349; https://doi.org/10.3390/ijms25063349 - 15 Mar 2024
Viewed by 507
Abstract
Previous studies have shown that inorganic arsenic (iAs) exposure may be associated with genotoxic and cytotoxic effects. The aim of this study was to evaluate the relationship between several polymorphisms in AS3MT and APOE genes and urinary As and the relationship between these [...] Read more.
Previous studies have shown that inorganic arsenic (iAs) exposure may be associated with genotoxic and cytotoxic effects. The aim of this study was to evaluate the relationship between several polymorphisms in AS3MT and APOE genes and urinary As and the relationship between these polymorphisms and pregnancy loss. We determined urinary As concentrations and performed genotyping analysis in 50 cases of spontaneous pregnancy loss and 50 controls, matched to cases on gestational age. The most frequently identified AS3MT polymorphisms in both cases and controls were in rs10748835 (80% cases and 68% controls), rs3740400 (78% cases and 64% controls), rs7085104 (74% cases and 48% controls), and rs1046778 (62% cases and 54% controls). We identified 30 different haplotypes in AS3MT SNPs, with four predominant haplotypes (>8%). Cases with Haplotype 1 had four-fold higher urinary DMA and two-fold higher MMA concentration than those without this haplotype, the MMA levels were lower in cases and controls with Haplotype 4 compared to Haplotype 1, and the DMA levels were significantly lower in cases with Haplotype 4 compared to Haplotype 3. Cases with Haplotype 1 had higher levels of all analyzed biomarkers, suggesting that Haplotype 1 may be associated with greater exposure to iAs and tobacco smoke. Our results suggest the importance of the AS3MT gene in iAs metabolism among pregnant women with low-level drinking water iAs exposure. Full article
(This article belongs to the Special Issue Molecular Advances in Obstetrical and Gynaecological Disorders)
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