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State-of-the-Art Bioactives and Nutraceuticals in Australia
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State-of-the-Art Bioactives and Nutraceuticals in Australia

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 5149

Special Issue Editor

Prof. Dr. Charles Brennan

E-Mail Website
Guest Editor
School of Science, RMIT University, P.O. Box 2474, Melbourne, VIC 3001, Australia
Interests: food science and human nutrition; biochemical digestibility; metabolic diseases; food function and structure
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to publish contributions that report on novel research findings regarding bioactive compounds and nutraceutical products in Australia. We welcome submissions and studies on nutritional applications using biological, chemical, cellular, molecular, and immunological methods. Topics include, but are not limited to:

  • the discovery of novel bioactive natural products
  • the role of these products in manipulating food structure and hence potential physiological mediation for human nutrition
  • the use of in vitro and in vivo bioactivity research using cell lines and animal models as exemplars of human physiology

The only limitation is that the main part of the study has to have been carried out in Australia or by Australian researchers.

Importantly, the exact active ingredient of natural origin extract must be reported in the submitted research manuscript, since papers describing the effects of mixed extraction from natural origin are not in the scope of the journal.

Prof. Dr. Charles Brennan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive
  • nutraceutical
  • nutrient
  • health
  • diet
  • functional food
  • obesity
  • diabetes
  • cancer
  • cardiovascular and cerebrovascular diseases
  • vitamins
  • proteins
  • peptides
  • polysaccharides
  • carotenoids
  • polyphenols
  • phytosterols and isoflavones
  • saponins
  • phytic acid
  • probiotics
  • prebiotics
  • enzymes
  • flavonoids
  • caffeine
  • carnitine
  • choline
  • creatine
  • dithiolthiones
  • phytoestrogens
  • glucosinolates

Published Papers (2 papers)

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Research

13 pages, 607 KiB  
Communication
Identification of Annonaceous Acetogenins and Alkaloids from the Leaves, Pulp, and Seeds of Annona atemoya
by Bassam S. M. Al Kazman, Joanna Elizabeth Harnett and Jane Rouse Hanrahan
Int. J. Mol. Sci. 2023, 24(3), 2294; https://doi.org/10.3390/ijms24032294 - 24 Jan 2023
Viewed by 2304
Abstract
Annonaceae is a large family composed of more than 119 genera and more than 2500 species that are distributed in both tropical and subtropical areas. The Annona genus is a member of Annonaceae family, which encompasses about 175 species, most of which are [...] Read more.
Annonaceae is a large family composed of more than 119 genera and more than 2500 species that are distributed in both tropical and subtropical areas. The Annona genus is a member of Annonaceae family, which encompasses about 175 species, most of which are native to Brazil and tropical America. This plant is commonly found on tropical and subtropical continents. Annona atemoya is a commercially important hybrid of A. squamosa and A. cherimola. Phytochemical investigations of A. atemoya leaves, fruit, and seeds have been conducted in limited studies. The purpose of this study was to investigate the constituents of the leaves, fruit pulp, and seeds of A. atemoya because few studies have reported their constituents. Annonaceous acetogenins were identified in the leaves and pulp of A. atemoya for the first time. Twenty compounds were identified: sixteen were acetogenins and four were alkaloids. Additionally, two compounds were isolated, and their structures were confirmed by spectroscopic analysis and compared with the results of previous studies. The concentration of acetogenins in the pulp was very low compared with that in the leaves, whereas the seeds were found to contain the highest concentrations and greatest diversity of compounds. Full article
(This article belongs to the Special Issue State-of-the-Art Bioactives and Nutraceuticals in Australia)
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19 pages, 2729 KiB  
Article
Identification of Phenolics Profile in Freeze-Dried Apple Peel and Their Bioactivities during In Vitro Digestion and Colonic Fermentation
by Hafza Fasiha Zahid, Akhtar Ali, Chaminda Senaka Ranadheera, Zhongxiang Fang and Said Ajlouni
Int. J. Mol. Sci. 2023, 24(2), 1514; https://doi.org/10.3390/ijms24021514 - 12 Jan 2023
Cited by 15 | Viewed by 2349
Abstract
Freeze-dried apple peel powder (Fd-APP) was subjected to in vitro digestion and colonic fermentation to evaluate the variations in its phenolic composition, bioactivities (antioxidant activity, α-amylase, and α-glucosidase inhibition), and fecal metabolic outputs. A total of 88 phenolics were tentatively identified, of which [...] Read more.
Freeze-dried apple peel powder (Fd-APP) was subjected to in vitro digestion and colonic fermentation to evaluate the variations in its phenolic composition, bioactivities (antioxidant activity, α-amylase, and α-glucosidase inhibition), and fecal metabolic outputs. A total of 88 phenolics were tentatively identified, of which 51 phenolic compounds were quantitated in Fd-APP sample extracts before digestion, and 34 were released during subsequent phases of digestion. Among these, phenolic acids showed the highest bio accessibility index (BI) of 68%, followed by flavonoids (63%) and anthocyanins (52%). The inhibitory functions of Fd-APP extract against α-amylase and α-glucosidase pre- and post-digestion were moderate and ranged from 41.88 to 44.08% and 35.23 to 41.13%, respectively. Additionally, the antioxidant activities revealed a significant (p ≤ 0.05) decline during the in vitro digestion. However, the colonic fermentation stage presented different products where the intact parent phenolic compounds present in Fd-APP were utilized by gut microbes and produced various phenolic metabolites such as 3- hydroxyphenyl acetic acid (3-HPAA), ferulic acid (FA), 3-(4-hydroxyphenyl) propionic acid (3,4 HPPA) and 4- hydroxybenzoic acid (4-HBA). Furthermore, colonic fermentation of Fd-APP accelerated the production of short-chain fatty acids (SCFAs), with acetic acid being the most prevalent (97.53 ± 9.09 mM). The decrease in pH of fermentation media to 4.3 significantly (p ≤ 0.05) enhanced counts of Bifidobacterium (10.27 log CFU/mL), which demonstrated the potential prebiotic effects of Fd-APP. These findings indicated that the consumption of apple peel as a constituent of novel functional foods may support and protect the intestinal microbiota and consequently promote human health. Full article
(This article belongs to the Special Issue State-of-the-Art Bioactives and Nutraceuticals in Australia)
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