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Molecular Studies in Endocrinology and Reproductive Biology—Second Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 840

Special Issue Editor

Special Issue Information

Dear Colleagues,

Reproductive endocrinology describes the hormones and control mechanisms that regulate reproduction. Disorders of reproductive endocrinology can occur due to abnormal changes anywhere in the hypothalamus–pituitary–gonadal axis, and can include a wide range of symptoms, including infertility, hirsutism, virilization, oligomenorrhea, and amenorrhea in women, and infertility and altered sexual function in men. This Special Issue focused on the approach to the diagnosis and evaluation of disorders of the reproductive endocrinology system, with a special emphasis on the roles of obesity, hypothyroidism, and PCO in infertility. The importance of epigenetic factors and evidence-based treatments is welcome to be addressed as well. Of particular interest are stimulation protocols during IVF, with a special reference to the benefits and pitfalls of these protocols. The hormonal profile of the cord blood in IVF babies compared to regular babies is also a highly prevalent topic we are interested in. Please note that papers published in the International Journal of Molecular Sciences are encouraged to include results at the molecular level. Both original research articles and reviews on these topics are welcome.

First Edition of this Special Issue: Molecular Studies in Endocrinology and Reproductive Biology.

Prof. Dr. Gábor L. Kovács
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive endocrinology
  • molecular research
  • IVF
  • epigenetic factors
  • obesity

Published Papers (1 paper)

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Research

17 pages, 1513 KiB  
Article
Follicular Fluid Proteomic Analysis of Women Undergoing Assisted Reproduction Suggests That Apolipoprotein A1 Is a Potential Fertility Marker
by Csilla Kurdi, János Schmidt, Zoltán Horváth-Szalai, Péter Mauchart, Krisztina Gödöny, Ákos Várnagy, Gábor L. Kovács and Tamás Kőszegi
Int. J. Mol. Sci. 2024, 25(1), 486; https://doi.org/10.3390/ijms25010486 - 29 Dec 2023
Cited by 1 | Viewed by 749
Abstract
Infertility affects millions worldwide, posing a significant global health challenge. The proteomic analysis of follicular fluid provides a comprehensive view of the complex molecular landscape within ovarian follicles, offering valuable information on the factors influencing oocyte development and on the overall reproductive health. [...] Read more.
Infertility affects millions worldwide, posing a significant global health challenge. The proteomic analysis of follicular fluid provides a comprehensive view of the complex molecular landscape within ovarian follicles, offering valuable information on the factors influencing oocyte development and on the overall reproductive health. The follicular fluid is derived from the plasma and contains various proteins that can have different roles in oocyte health and infertility, and this fluid is a critical microenvironment for the developing oocytes as well. Using the high-performance liquid chromatography-mass spectrometry method, we investigated the protein composition of the follicular fluid, and after classification, we carried out relative quantification of the identified proteins in the pregnant (P) and non-pregnant (NP) groups. Based on the protein–protein interaction analysis, albumin and apolipoprotein A1 (ApoA1) were found to be hub proteins, and the quantitative comparison of the P and NP groups resulted in a significantly lower concentration of ApoA1 and high-density lipoprotein cholesterol in the P group. As both molecules are involved in the cholesterol transport, we also investigated their role in the development of oocytes and in the prediction of fertility. Full article
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