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Impact of Signaling Pathways on Endothelial Cells: From Homeostasis to Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 243

Special Issue Editor

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Guest Editor
Biosanté Unit U1292, Grenoble Alpes University, INSERM, CEA, F-38000 Grenoble, France
Interests: endothelial cells; signaling pathways; BMP signaling; hereditary hemorrhagic telangiectasia, angiogenesis; endothelial resilience; vascular malformations

Special Issue Information

Dear Colleagues,

Endothelial cells receive continuous molecular inputs from blood and surrounding tissues, and secrete, in turn, angiocrine factors that regulate tissue homeostasis and development. Dysregulation in the communication between endothelial cells and surrounding tissues is involved in numerous pathologies. Recent advances in vascular biology have revealed that unique combinations of signaling pathways and hemodynamics define the endothelial microenvironments motivating and supporting endothelial cell heterogeneity, not only between organs, but also within a given organ. This inherent endothelial heterogeneity is key for blood and lymphatic vessel development, function and regeneration. Thus, an enhanced understanding of how signaling pathways and hemodynamics affect the growth and maintenance of blood and lymphatic vessels of different organs, sizes and morphologies is required in order to engineer the vascularization of organoids or regenerating tissues, and to normalize vascular and lymphatic malformations. 

In this Special Issue of the International Journal of Molecular Sciences, we aim to publish original research works focusing on endothelial signaling pathways in health and diseases. Please note that the International Journal of Molecular Sciences is a journal of molecular science, and thus pure clinical or model studies will not be suitable. However, clinical or pure model submissions alongside biomolecular experiments are welcome.

Dr. Nicolas Ricard
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • endothelial cells
  • signaling pathways
  • endothelial homeostasis
  • vascular diseases
  • vascular malformations
  • lymphatic malformations
  • endothelial heterogeneity
  • intercellular communication

Published Papers

This special issue is now open for submission.
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