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Special Issue "Sticky Mechanisms Governing Cancer Progression: Role of Integrins and Cadherins"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 152

Special Issue Editors

Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Interests: signal transduction; cell adhesion; molecular markers; 3D tissue culture; epithelial ovarian cancer
Special Issues, Collections and Topics in MDPI journals
Department of Molecular Biotechnology and Health Sciences, MBC - Molecular Biotechnology Center “Guido Tarone", University of Torino, Turin, Italy
Interests: cell signaling; integrins; ECM; adaptor proteins; p140Cap; p130Cas; breast cancer; Her2; neuroblastoma; proteomics

Special Issue Information

Dear Colleagues,

Cell–cell and cell–extracellular matrix adhesion are essential for tissue integrity and human health. In cancer, adhesive machinery is involved in nearly every step of cancer progression, from primary tumour development to metastasis. Adhesive interactions contribute to sensing, transmitting and responding to external stimuli affecting not only cytoskeletal rearrangements but also modulating the activation of signalling molecules which support the survival, growth, invasion and acquirement of cancer stem cell characteristics and drug resistance. Cadherins and integrins are the main receptors that mediate adhesive interactions through the assembly of structural and signalling complexes, such as the cell's adhesome at cell–matrix adhesion sites. The integrin-mediated stiffening and remodelling of the tumour stroma are also key steps in cancer progression. The elucidation of a plethora of integrin- and cadherin-dependent mechanisms will enable us to gain deeper insights into the growth, motility and invasiveness of cancer cells and pave the way for the development of targeted therapeutic treatments which interfere with metastatic progression in cancer patients.

This Special Issue calls for original research papers, reviews and perspectives that address the current knowledge and the most recent progress regarding intracellular mechanisms governing cancer cell behaviour following adhesion mediated by integrins and cadherins. Emphasis will be also placed on ex vivo/in vitro models to recapitulate the multicellular interactions occurring during cancer progression, as well as the identification of new approaches to inhibit these interactions.

Dr. Antonella Tomassetti
Prof. Dr. Paola Defilippi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.



  • integrins
  • cadherins
  • adhesome
  • adhesive signaling
  • matrix stiffness
  • tri-dimensional and ex vivo in vitro models

Published Papers

There is no accepted submissions to this special issue at this moment.
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