Special Issue "Sticky Mechanisms Governing Cancer Progression: Role of Integrins and Cadherins"
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 152
Interests: signal transduction; cell adhesion; molecular markers; 3D tissue culture; epithelial ovarian cancer
Special Issues, Collections and Topics in MDPI journals
Interests: cell signaling; integrins; ECM; adaptor proteins; p140Cap; p130Cas; breast cancer; Her2; neuroblastoma; proteomics
Cell–cell and cell–extracellular matrix adhesion are essential for tissue integrity and human health. In cancer, adhesive machinery is involved in nearly every step of cancer progression, from primary tumour development to metastasis. Adhesive interactions contribute to sensing, transmitting and responding to external stimuli affecting not only cytoskeletal rearrangements but also modulating the activation of signalling molecules which support the survival, growth, invasion and acquirement of cancer stem cell characteristics and drug resistance. Cadherins and integrins are the main receptors that mediate adhesive interactions through the assembly of structural and signalling complexes, such as the cell's adhesome at cell–matrix adhesion sites. The integrin-mediated stiffening and remodelling of the tumour stroma are also key steps in cancer progression. The elucidation of a plethora of integrin- and cadherin-dependent mechanisms will enable us to gain deeper insights into the growth, motility and invasiveness of cancer cells and pave the way for the development of targeted therapeutic treatments which interfere with metastatic progression in cancer patients.
This Special Issue calls for original research papers, reviews and perspectives that address the current knowledge and the most recent progress regarding intracellular mechanisms governing cancer cell behaviour following adhesion mediated by integrins and cadherins. Emphasis will be also placed on ex vivo/in vitro models to recapitulate the multicellular interactions occurring during cancer progression, as well as the identification of new approaches to inhibit these interactions.
Dr. Antonella Tomassetti
Prof. Dr. Paola Defilippi
Manuscript Submission Information
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- adhesive signaling
- matrix stiffness
- tri-dimensional and ex vivo in vitro models