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Iron Dyshomeostasis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1399

Special Issue Editors

Department of Biosciences, Biotechnology and Environment, University of Bari, Via Orabona 4, 70125 Bari, Italy
Interests: mitochondrial diseases; mitochondrial transport proteins; mitochondrial metabolism; oxidative stress; iron metabolism; iron dyshomeostasis
Department of Life Sciences, Brunel University London, London, UK
Interests: neurodegeneration; Friedreich’s ataxia; metabolomics; mouse models; oxidative stress; mitochondrial function

Special Issue Information

Dear Colleagues, 

Iron plays a crucial role in many physiological processes of the human body. A plethora of highly conserved regulatory and signaling pathways comprising metal uptake, transport, release, cellular storage, and metal recycling tightly control the dynamics of iron distribution inside the cells. Iron dyshomeostasis is usually associated with altered distribution and accumulation of iron in different compartments of cells. It is connected to multifactorial cellular dysfunction, causing oxidative stress, iron-induced lipid peroxidation, inflammatory responses, and ferroptosis, a programmed cell death process associated with iron dysregulation. It is supposed to be linked to many pathological processes, especially blood disorders, cancer, metabolic disorders, neurodegenerative diseases, as well as viral infections. In this collection, we will present an updated view of iron dyshomeostasis, discussing the associations with pathological processes. It will be also discussed how accumulated knowledge on this process is helping the creation of novel therapeutic strategies.

Dr. Carlo Marya Thomas Marobbio
Dr. Sara Anjomani Virmouni
Guest Editors

Manuscript Submission Information

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Keywords

  • iron metabolism

  • iron dyshomeostasis
  • ferroptosis
  • oxidative stress
  • mitochondrial disease

Published Papers (1 paper)

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Review

17 pages, 1222 KiB  
Review
The Role of Cellular Defense Systems of Ferroptosis in Parkinson’s Disease and Alzheimer’s Disease
by Jie Chu, Jingwen Li, Lin Sun and Jianshe Wei
Int. J. Mol. Sci. 2023, 24(18), 14108; https://doi.org/10.3390/ijms241814108 - 14 Sep 2023
Cited by 2 | Viewed by 1116
Abstract
Parkinson’s disease (PD) and Alzheimer’s disease (AD) are the most common rapidly developing neurodegenerative diseases that lead to serious health and socio-economic consequences. Ferroptosis is a non-apoptotic form of cell death; there is growing evidence to support the notion that ferroptosis is involved [...] Read more.
Parkinson’s disease (PD) and Alzheimer’s disease (AD) are the most common rapidly developing neurodegenerative diseases that lead to serious health and socio-economic consequences. Ferroptosis is a non-apoptotic form of cell death; there is growing evidence to support the notion that ferroptosis is involved in a variety of pathophysiological contexts, and there is increasing interest in the role of ferroptosis in PD and AD. Simultaneously, cells may have evolved four defense systems to counteract the toxic effects of ferroptosis occasioned by lipid peroxidation. This review, which focuses on the analysis of ferroptosis in the PD and AD context, outlines four cellular defense systems against ferroptosis and how each of them is involved in PD and AD. Full article
(This article belongs to the Special Issue Iron Dyshomeostasis)
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