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The Role of Hormones and Nutrients in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 110

Special Issue Editor

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Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Interests: cellular stress response; redox homeostasis; aging; neuroprotection; hormesis; nutritional antioxidants; mitochondrial medicine; brain resilience

Special Issue Information

Dear Colleagues,

The interplay of sensory nutrients and steroid hormones has gained considerable attention for enhancing stress resilience in health and disease. Sensory nutrients, including polyphenols and the more bioavailable polyphenol-combined nanoparticles, but also vitamin C, vitamin E, vitamin D, and omega-3 fatty acids, have been shown to improve blood–brain barrier (BBB) permeability, steroid homeostasis, and brain function, thus inhibiting oxidative stress, inflammation linked to the pathogenesis of nervous system disorders. Interestingly, polyphenols display biphasic dose–response effects by activating at the minimum dose the Nrf2 pathway and the downstream antioxidant proteins, heme oxygenase-1 upregulated by curcumin, and sirtuin-1 activated by resveratrol to block reactive oxygen species (ROSs) and neural toxicity. Impaired Nrf2 and steroid hormone signaling in the brain may exacerbate selective susceptibility under neuroinflammatory conditions to the onset and progression of psychiatric disorders, such as anxiety and depression, and other neurological disorders due to the vulnerability of neurons to oxidative stress. The proposal of this Special Issue is to collect original research and review articles focused on sensory nutrients targeting the Nrf2 pathway to regulate steroid hormones and explore the underlying molecular mechanisms using innovative in vitro and in vivo technologies for the development of promising neuroprotective strategies and precise as well as personalized nutritional therapies in order to prevent or attenuate oxidative stress, inflammation, and consequently promote brain health.

Dr. Maria Scuto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • sensory nutrients
  • steroid hormones
  • oxidative stress
  • inflammation
  • Nrf2 pathway
  • neurodegenerative disorders
  • psychiatric diseases
  • personalized nutritional therapy
  • organoid technology

Published Papers

This special issue is now open for submission.
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