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Special Issue "Plant Disease Response to High-Impact Phytopathogens: New Approaches and Perspectives"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1174

Special Issue Editor

Centro de Biodiversidad y Desarrollo Sostenible, Departamento de Sistemas y Recursos Naturales, E.T.S.I. Montes, Forestal y del Medio Natural, Universidad Politécnica de Madrid, C/ Antonio Nováis 10, 28040 Madrid, Spain
Interests: global warming; molecular phytopathology; biotechnology; biodiversity; biopesticides; environmentally friendly strategies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last decade, global warming has affected plant–pathogen interactions. Due to raising temperatures crop survival and productivity have diminished, soil biodiversity has been lost, and there have been difficulties restoring forested and non-forested environments. These circumstances necessitate the adoption of new strategies to combat plant diseases in agriculture and forest environments. Phytopathogens try to survive by adapting to changing conditions in their host, location, and lifestyle. Those in non-temperate regions are beginning to infect plant species because the extreme climatic events associated with global warming, such as long periods of drought, high or low levels of rain, snow, storms, longer wildfire seasons, or higher water vapor levels in the atmosphere, are affecting their impact and dispersion capacities.

In this context, for this Special Issue we intend to collect recent results and research on high-impact phytopathogens and new biotechnological approaches to combat them using environmentally friendly strategies in the “omics” field.

We welcome different types of papers, including reviews, about high-impact phytopathogens, the molecular mechanism of plant responses, metabolomics, transcriptomics, epigenomics or single cell sequencing in the host and in the pathogen, as well as new biotechnological approaches. In this Special Issue, we will also include the latest analyses and findings to address the problem of high-impact phytopathogens  in a global warming context.

Dr. Marta Berrocal-Lobo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • plant disease
  • epigenetics
  • plant immunity
  • phytopathogens
  • priming molecules
  • plant pathology
  • histones
  • RNAs
  • methylation

Published Papers (1 paper)

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Comparative Transcriptome Analysis Reveals Novel Candidate Resistance Genes Involved in Defence against Phytophthora cactorum in Strawberry
Int. J. Mol. Sci. 2023, 24(13), 10851; https://doi.org/10.3390/ijms241310851 - 29 Jun 2023
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Crown rot, caused by Phytophthora cactorum, is a devastating disease of strawberry. While most commercial octoploid strawberry cultivars (Fragaria × ananassa Duch) are generally susceptible, the diploid species Fragaria vesca is a potential source of resistance genes to P. cactorum. [...] Read more.
Crown rot, caused by Phytophthora cactorum, is a devastating disease of strawberry. While most commercial octoploid strawberry cultivars (Fragaria × ananassa Duch) are generally susceptible, the diploid species Fragaria vesca is a potential source of resistance genes to P. cactorum. We previously reported several F. vesca genotypes with varying degrees of resistance to P. cactorum. To gain insights into the strawberry defence mechanisms, comparative transcriptome profiles of two resistant genotypes (NCGR1603 and Bukammen) and a susceptible genotype (NCGR1218) of F. vesca were analysed by RNA-Seq after wounding and subsequent inoculation with P. cactorum. Differential gene expression analysis identified several defence-related genes that are highly expressed in the resistant genotypes relative to the susceptible genotype in response to P. cactorum after wounding. These included putative disease resistance (R) genes encoding receptor-like proteins, receptor-like kinases, nucleotide-binding sites, leucine-rich repeat proteins, RPW8-type disease resistance proteins, and ‘pathogenesis-related protein 1’. Seven of these R-genes were expressed only in the resistant genotypes and not in the susceptible genotype, and these appeared to be present only in the genomes of the resistant genotypes, as confirmed by PCR analysis. We previously reported a single major gene locus RPc-1 (Resistance to Phytophthora cactorum 1) in F. vesca that contributed resistance to P. cactorum. Here, we report that 4–5% of the genes (35–38 of ca 800 genes) in the RPc-1 locus are differentially expressed in the resistant genotypes compared to the susceptible genotype after inoculation with P. cactorum. In particular, we identified three defence-related genes encoding wall-associated receptor-like kinase 3, receptor-like protein 12, and non-specific lipid-transfer protein 1-like that were highly expressed in the resistant genotypes compared to the susceptible one. The present study reports several novel candidate disease resistance genes that warrant further investigation for their role in plant defence against P. cactorum. Full article
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