Special Issue "Tissue Regeneration in Autism Spectrum Disorders"
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 200
Interests: tissue regeneration; bioactive materials; cell delivery systems; nanostructured materials
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Patients with autism spectrum disorders suffer from less-examined musculoskeletal and orthopedic issues, which hints to a pathophysiological mechanism associated with behavioral problems. Orthopedic manifestations range from toe walking to scoliosis. Furthermore, reduced bone thickness is common and can increase the risk of bone fractures. Evidence of the neurodegenerative aspects of autism has been reported. Therefore, the regenerative capacity of tissue in patients with autism is affected. Bone healing has not been studied in autism models to assess whether delayed healing can occur. On the positive side, understanding tissue regeneration in autistic mouse models allows us to explore cellular interplay, and to propose therapeutic strategies. Understanding tissue regeneration in bones can lead to treatment strategies that ease the orthopedic symptoms suffered by patients with autism. Furthermore, the regenerative capacity of tissue can be systematically addressed to enhance the quality of life of those patients. Regenerative medicine completely restores tissue structure and function by supporting endogenous regeneration. In cases of diseased tissue, regenerative medicine aims to restore its function and structure to recapitulate the healthy tissue. Therefore, it is essential to identify the blueprint or shortfalls that impair tissue regeneration and development. Although musculoskeletal manifestations are common symptoms associated with autism spectrum disorder, a basic understanding of how tissue is influenced in autistic mice models is essential for the successful implementation of regenerative medicine approaches. The proposed project approaches autism spectrum disorder as a neurobiological condition, rather than a neurobehavioral condition. We hypothesize that the impaired development of the mesenchyme affects bone quality in autistic mice and contributes to neurobiological impairment.
Dr. Thaqif El Khassawna
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