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The Role of Cytokines in Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 22 May 2024 | Viewed by 1559

Special Issue Editor


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Guest Editor
Institute of Fundamental Medicine and Biology, Kazan Federal University, OpenLab, 420008 Kazan, Russia
Interests: immune response; cytotoxic T cells; B cells; antibodies; autoantibodies; cytokines; antibody dependent cytotoxicity; pathogen associated molecular patterns; pathogen recognition receptors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cytokines are a diverse group of proteins that are critical for regulating immune responses and inflammation as they facilitate communication between immune cells in response to various stimuli, including pathogens, tissue damage, and cancer cells. An imbalance in cytokine production and activity can lead to autoimmune disorders, chronic inflammation, and cancer.

The activation of cytokines is essential for initiating and maintaining immune responses to pathogen-associated patterns. Various immune cells, such as macrophages, dendritic cells, and T cells, produce cytokines influenced by the nature of pathogen-associated patterns, genetics, and environmental exposure.

We invite the submission of original research papers, case reports, clinical trials, and review articles on the following potential topics:

  1. Molecular regulation of cytokine activation.
  2. Cytokine roles in infection, cancer, and autoimmune disease pathogenesis.
  3. Molecular mechanisms of novel therapeutic approaches targeting cytokines.
  4. Monoclonal antibodies for treatment of cytokine-associated disorders.
  5. Genetic and epigenetic factors contributing to cytokine activation.
  6. The role of PAMPS, DAMPS, and PRRs in cytokine activation.
  7. Environmental factors influencing cytokine activation.

Dr. Svetlana Khaiboullina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytokines
  • inflammation
  • immune response
  • genetics
  • epigenetics
  • disease
  • infection
  • pathogen-associated molecular patterns
  • damage-associated molecular patterns
  • pattern-recognizing receptors
  • treatment

Published Papers (1 paper)

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13 pages, 1356 KiB  
Hypothesis
Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in COVID-19
by Zoia R. Korobova, Natalia A. Arsentieva and Areg A. Totolian
Int. J. Mol. Sci. 2023, 24(17), 13083; https://doi.org/10.3390/ijms241713083 - 23 Aug 2023
Viewed by 1168
Abstract
Macrophage-derived chemokine (MDC/CCL22) is a chemokine of the C-C subfamily. It is involved in T-cellular maturation and migration. Our previous research shows that plasma CCL22/MDC tends to show a statistically significant depletion of concentrations in acute patients and convalescents when compared to healthy [...] Read more.
Macrophage-derived chemokine (MDC/CCL22) is a chemokine of the C-C subfamily. It is involved in T-cellular maturation and migration. Our previous research shows that plasma CCL22/MDC tends to show a statistically significant depletion of concentrations in acute patients and convalescents when compared to healthy donors. In the current work, we investigate existing views on MDC/CCL22 dynamics in association with various pathologies, including respiratory diseases and, specifically, COVID-19. Additionally, we present our explanations for the observed decrease in MDC/CCL22 concentrations in COVID-19. The first hypothesis we provide implies that viral products bind to MDC/CCL22 and block its activity. Another explanation for this phenomenon is based on dendritic cells population and the inhibition of their function. Full article
(This article belongs to the Special Issue The Role of Cytokines in Diseases)
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