Special Issue "Zinc and Manganese in Human Health and Disease"
Deadline for manuscript submissions: 30 November 2023 | Viewed by 2174
Metal ion homeostasis is fundamental for life. Specifically, transition metals iron, manganese, and zinc play a pivotal role in mitochondrial metabolism and energy generation, anti-oxidation defense, transcriptional regulation, and the immune response. The misregulation of expression or mutations in ion carriers and the corresponding changes in Mn2+ and Zn2+ levels suggest that these ions play a pivotal role in cancer progression. Coordinated changes in Mn2+ and Zn2+ ion carriers have been detected in cancers, suggesting that particular mechanisms influenced by both ions might be required for the growth of cancer cells, metastasis, and immune evasion.
Mechanistically, Zn and Mn effects converge on mitochondria-induced apoptosis, transcriptional regulation, and immune response regulation by the cGAS-STING signaling pathway. Both Zn and Mn influence cancer progression and impact treatment efficacy in animal models and clinical trials.
In this Special Issue, we invite papers covering all aspects of Zn- and Mn-related biology, such as development of biosensors, enzyme kinetics, drug development including nanomaterials, biomarker research, and clinical applications, interaction with other transition metals (such as Fe and Mg), and Ca and Mg homeostasis and signaling.
Dr. Julian Markovich Rozenberg
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- metal ion homeostasis and signaling
- mitochondrial metabolism
- energy generation
- anti-oxidation defense
- transcriptional regulation
- immune response
- enzyme kinetics
- drug development
- biomarker research
- clinical application
- interaction with other transition metals
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.