Special Issue "Emerging Roles of Microtubule-Associated Serine/Threonine (MAST) Kinases in Cell Biology and Biomedical Research"
Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 760
MAST kinases comprise an evolutionary conserved branch of the AGC family of protein kinases. Since the discovery of the founding member MAST2 in 1993, three additional family members have been identified in mammals, which are broadly expressed across various tissues including the brain, heart, lung, liver, and kidney. Importantly, MAST kinases have been implicated in several severe human diseases, such as breast and liver cancer, inflammatory bowel disease, rabies virulence, cystic fibrosis, and neuronal disorders. Despite several reports on potential substrates and binding partners of MAST kinase, the mechanistic basis for their involvement in human diseases remain rather under investigated, in particular concerning the identification of substrates and the regulation of MAST kinase activity, which still remain rather obscure.
This purpose of this Special Issue is to establish a current profile of the field of MAST kinases and to provide a platform for experts working on any aspect of MAST kinase biology in order to encourage new interactions through a collection of primary research articles, perspective articles, and review articles. We would like to invite submissions concerning biochemistry, cell and molecular biology, and research in the context of developmental systems and biomedical research.
Prof. Dr. Hans-Arno Müller
Manuscript Submission Information
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- protein kinases
- microtubule-associated serine/threonine kinases
- model organisms
- human disease