Special Issue "Ubiquitin Receptors and Associated Mechanisms Involved in Targeting Proteins Modified with Diverged Ubiquitin Signals to Distinct Cellular Processes"
Deadline for manuscript submissions: 15 November 2023 | Viewed by 331
Ubiquitination is a pivotal regulatory mechanism for nearly all major cellular processes. For all eukaryotic organisms, it is essential for the growth and development of and the response to biotic and abiotic stresses. When catalyzing using many conjugation and deconjugation enzymes, the small and evolutionary conserved ubiquitin could be assembled and dynamically modulated on various protein substrates into highly diverged ubiquitin signals: ubiquitin monomer and ubiquitin chains with homogeneous, mixed, or branched linkages of various lengths. Depending on the different ubiquitin signals assembled, the outcomes of modified substrates could be rather distinct such as degradation by 26S proteasome, endocytosis, or the autophagy pathway. Various ubiquitin signals could also provide interfaces for relaying signal transduction pathways or for recruiting epigenetic regulatory and DNA repairing machineries. While the majority of ubiquitination studies focus on conjugation and deconjugation enzyme components and their corresponding physiological functions, little information is available for specific ubiquitin signals assembled on particular substrates in vivo or on corresponding ubiquitin binding factors for deciphering various ubiquitin signals and associated mechanisms en route to various cellular processes. This Special Issue will be focused on ubiquitin signal assembles on specific substrates and ubiquitin binding proteins involved in deciphering various ubiquitin signals for various cellular processes, such as various degradation pathways, signal transduction, epigenetic regulation, and DNA repairing. All related original articles, up-to-date reviews, and methodology papers will all be considered.
Dr. Hong-yong Fu
Manuscript Submission Information
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- ubiquitin signals
- ubiquitin binding
- ubiquitin receptor
- 26S proteasome
- epigenetic regulation
- DNA repair