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Special Issue "New Insight into Therapeutic Potential of Targeted Nanoparticles"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 218

Special Issue Editor

National Research Council, Institute for Biomedical Research and Innovation (CNR-IRIB), Via Ugo la Malfa, 153, 90146 Palermo, Italy
Interests: cancer targeted therapy; theranostics; carbon dots; chemo-phototherapy combination; pathway focused gene expression analyses; biomedical application
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Targeted nanoparticles have gained significant attention in the field of biomedicine due to their promising therapeutic potential. They are designed to carry therapeutic agents, such as drugs or DNA/RNA, and deliver them to specific sites within the body, thereby enhancing their effectiveness and minimizing potential side effects.

One key advantage is their ability to specifically accumulate at the desired site of action. This works by functionalizing the surface of nanoparticles with ligands or antibodies, thus reducing off-target effects and enhancing therapeutic efficacy.

Another benefit is their ability to improve drug solubility, stability, and bioavailability. Therapeutic agents, particularly hydrophobic drugs, face challenges in being efficiently delivered to their target sites. Nanoparticles can encapsulate these drugs, protecting them from degradation and enhancing their solubility in physiological fluids. This improves their pharmacokinetics and allows for controlled release, leading to prolonged drug activity and reduced dosing frequency.

They also provide opportunities for combination therapy. Multiple therapeutic agents, such as drugs with different mechanisms of action or nucleic acids, can be encapsulated within the same nanoparticle system. This allows for synergistic effects, combinatorial therapy, and the potential to overcome drug resistance. Additionally, nanoparticles can be engineered to respond to specific stimuli, such as pH, temperature, or enzymatic activity, enabling the triggered release of therapeutic agents at the desired site.

Furthermore, they offer new possibilities for imaging and diagnostics. By incorporating imaging agents, such as fluorescent probes or contrast agents, they can serve as both therapeutic and diagnostic tools.

This Special Issue aims to cover recent advances in all the various aspects of targeted nanoparticles exploitation. While the field is still rapidly evolving, the development and utilization of targeted nanoparticles have the potential to revolutionize the treatment and management of various diseases. The Special Issue aims also to provide a unique platform, offering valuable perspectives from experts in this field.

Dr. Aldo Nicosia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • targeted nanoparticles
  • theranostics
  • bioimaging
  • targeted therapy
  • photothermal therapy
  • combination therapy
  • controlled release
  • reduced side effects

Published Papers

This special issue is now open for submission.
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