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Genomics: Infectious Disease and Host-Pathogen Interaction 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1487

Special Issue Editor

Special Issue Information

Dear Colleagues,

Infectious diseases, which are disorders caused by pathogens such as bacteria, viruses, fungi, or parasites, pose a serious threat to humans, animals, and plants. Pathogens can interact with the host to suppress or evade the host immune systems in order to establish and disseminate the infections.

Unique genome features contribute largely to the events of host–pathogen interactions, governing the virulence level of pathogens and infection severity of the host. With the advancement of NGS and nanopore sequencing, it is now highly cost-effective to pursue genomic and transcriptomic studies. Recent research has shown that host–pathogen interaction can be bi-directionally modulated by small RNAs which come from unique genome loci. Under the current COVID-19 pandemic, there is a surge in the development of SARS-CoV-2 detection methods based on the study of phylogenomics and mutations of viral genomes.

We invite researchers to contribute original research articles and reviews focused on different genomics aspects of i) infectious diseases and ii) host–pathogen interactions.

Topics of interest include, but are not limited to, the following:

  • Genomics and transcriptomics;
  • Phylogenetics and evolution;
  • Small RNA regulations;
  • RNA biology (e.g., Dual-RNA-Seq);
  • Molecular pathogenesis;
  • Molecular detection.

Dr. Franklin W.N. Chow
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infectious diseases
  • NGS
  • small RNA
  • host-pathogen interaction
  • pathogen detection
  • viruses
  • fungi
  • parasites
  • bacteria
  • evolution

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Published Papers (1 paper)

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Research

20 pages, 2280 KiB  
Article
Reprogramming in Candida albicans Gene Expression Network under Butanol Stress Abrogates Hyphal Development
by Rajesh Anand, Mohammad Kashif, Awadhesh Pandit, Ram Babu and Agam P. Singh
Int. J. Mol. Sci. 2023, 24(24), 17227; https://doi.org/10.3390/ijms242417227 - 7 Dec 2023
Cited by 1 | Viewed by 1100
Abstract
Candida albicans is the causative agent of invasive fungal infections. Its hyphae-forming ability is regarded as one of the important virulence factors. To unravel the impact of butanol on Candida albicans, it was placed in O+ve complete human serum with butanol [...] Read more.
Candida albicans is the causative agent of invasive fungal infections. Its hyphae-forming ability is regarded as one of the important virulence factors. To unravel the impact of butanol on Candida albicans, it was placed in O+ve complete human serum with butanol (1% v/v). The Candida transcriptome under butanol stress was then identified by mRNA sequencing. Studies including electron microscopy demonstrated the inhibition of hyphae formation in Candida under the influence of butanol, without any significant alteration in growth rate. The numbers of genes upregulated in the butanol in comparison to the serum alone were 1061 (20 min), 804 (45 min), and 537 (120 min). Candida cells exhibited the downregulation of six hypha-specific transcription factors and the induction of four repressor/regulator genes. Many of the hypha-specific genes exhibited repression in the medium with butanol. The genes related to adhesion also exhibited repression, whereas, among the heat-shock genes, three showed inductions in the presence of butanol. The fungal-specific genes exhibited induction as well as repression in the butanol-treated Candida cells. Furthermore, ten upregulated genes formed the core stress gene set in the presence of butanol. In the gene ontology analysis, enrichment of the processes related to non-coding RNA, ribosome biosynthesis, and metabolism was observed in the induced gene set. On the other side, a few GO biological process terms, including biofilm formation and filamentous growth, were enriched in the repressed gene set. Taken together, under butanol stress, Candida albicans is unable to extend hyphae and shows growth by budding. Many of the genes with perturbed expression may have fitness or virulence attributes and may provide prospective sites of antifungal targets against C. albicans. Full article
(This article belongs to the Special Issue Genomics: Infectious Disease and Host-Pathogen Interaction 3.0)
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