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Food Bioactive Oligosaccharides, Polysaccharides and Exopolysaccharides, Their Health Functions and Implications in Food Industry

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2579

Special Issue Editors

Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Calea Manastur Street, 400372 Cluj-Napoca, Romania
Interests: nutrigenomics; metagenomics; metaproteomics; metabolomics; metatranscriptomics; understanding the molecular mechanisms of food compounds; molecular nutrition; personalised nutrition; personalised food; medical foods; aging and chronic disease; aging and NCDs; climate/environment, health, and improved nutrition; diet and cancer; dietary bioactive components; prebiotics fiber; nutrient-gene interactions; nutritional epidemiology; nutritional immunology and inflammation; obesity and microbiome; gut-brain axis; nutritional microbiology
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Special Issue Information

Dear Colleagues,

Dietary nondigestible polysaccharides such as nondigestible oligosaccharides (NDOs) are of extreme importance for gut microbiota, which degrade them and produce beneficial metabolites for human health.

The most studied ones, galacto-oligosaccharides (GOSs) and fructo-oligosaccharides (FOSs), are polymers with different degrees of polymerization, and the spectrum of oligosaccharides (OSHs) is directly correlated with the source of the enzymes used for the biocatalytic reaction.

Potential health benefits include a reduction in dysbiosis (intestinal transit disorders), cardiovascular disease, cancer, the regulation of the immune response, as well as the reduction in serum cholesterol levels.

Oligosaccharides, polysaccharides and exopolysaccharides are of great interest as favorable candidates for food grade expression systems such as synbiotic, metabiotic and postbiotic formulations such as nutraceuticals, functional foods or functional food ingredients.

Lactic acid bacteria (LAB), granted as being ‘generally recognized as safe’ (GRAS), produce extracellular polysaccharides or exopolysaccharides (EPSs) that play a crucial commercial role due to their industrial food physico-chemical properties, improving the rheology, texture and fermented product flavor and granting beneficial health effects, such as anticarcinogenic, immunostimulatory, antioxidant, antidiabetic and cholesterol-lowering properties. For this reason, EPSS represent an important food bioactive ingredient in the functional food design.

The aim of this Special Issue is to present recent advancements in the production, utilization and impact of all the mentioned saccharides on human health and their implications and utilization in the food industry.

Dr. Oana Lelia Pop
Prof. Dr. Ramona Suharoschi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bioactive oligosaccharides
  • human milk oligosaccharides
  • chitosan oligosaccharides fructo-oligosaccharides
  • polysaccharides
  • exopolysaccharides
  • gut microbiota
  • functional foods
  • nutrigenomics

Published Papers (1 paper)

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22 pages, 4465 KiB  
Metabiotics Signature through Genome Sequencing and In Vitro Inhibitory Assessment of a Novel Lactococcus lactis Strain UTNCys6-1 Isolated from Amazonian Camu-Camu Fruits
Int. J. Mol. Sci. 2023, 24(7), 6127; https://doi.org/10.3390/ijms24076127 - 24 Mar 2023
Cited by 2 | Viewed by 2039
Metabiotics are the structural components of probiotic bacteria, functional metabolites, and/or signaling molecules with numerous beneficial properties. A novel Lactococcus lactis strain, UTNCys6-1, was isolated from wild Amazonian camu-camu fruits (Myrciaria dubia), and various functional metabolites with antibacterial capacity were found. [...] Read more.
Metabiotics are the structural components of probiotic bacteria, functional metabolites, and/or signaling molecules with numerous beneficial properties. A novel Lactococcus lactis strain, UTNCys6-1, was isolated from wild Amazonian camu-camu fruits (Myrciaria dubia), and various functional metabolites with antibacterial capacity were found. The genome size is 2,226,248 base pairs, and it contains 2248 genes, 2191 protein-coding genes (CDSs), 50 tRNAs, 6 rRNAs, 1 16S rRNA, 1 23S rRNA, and 1 tmRNA. The average GC content is 34.88%. In total, 2148 proteins have been mapped to the EggNOG database. The specific annotation consisted of four incomplete prophage regions, one CRISPR-Cas array, six genomic islands (GIs), four insertion sequences (ISs), and four regions of interest (AOI regions) spanning three classes of bacteriocins (enterolysin_A, nisin_Z, and sactipeptides). Based on pangenome analysis, there were 6932 gene clusters, of which 751 (core genes) were commonly observed within the 11 lactococcal strains. Among them, 3883 were sample-specific genes (cloud genes) and 2298 were shell genes, indicating high genetic diversity. A sucrose transporter of the SemiSWEET family (PTS system: phosphoenolpyruvate-dependent transport system) was detected in the genome of UTNCys6-1 but not the other 11 lactococcal strains. In addition, the metabolic profile, antimicrobial susceptibility, and inhibitory activity of both protein–peptide extract (PPE) and exopolysaccharides (EPSs) against several foodborne pathogens were assessed in vitro. Furthermore, UTNCys6-1 was predicted to be a non-human pathogen that was unable to tolerate all tested antibiotics except gentamicin; metabolized several substrates; and lacks virulence factors (VFs), genes related to the production of biogenic amines, and acquired antibiotic resistance genes (ARGs). Overall, this study highlighted the potential of this strain for producing bioactive metabolites (PPE and EPSs) for agri-food and pharmaceutical industry use. Full article
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