Special Issue "Chemotherapeutics Based on Metals: Bioactivity and Mechanisms of Action"
Deadline for manuscript submissions: 20 December 2023 | Viewed by 241
Interests: medicinal chemistry; metal-based drugs; anticancer drugs; oxidative stress; organometallics
The severe side effects observed by patients undergoing chemotherapy with platinum drugs (cisplatin, carboplatin, oxaliplatin) are the main disadvantages in treatment of tumor diseases. Moreover, the onset of cancer chemoresistance to platinum-based chemotherapy represents an additional major limitation to its clinical practice. Therefore, approaches to overcome the toxicity and/or tumor resistance to platinum-containing chemotherapies dominate the field of non-platinum drugs. On the other hand, application of metals beyond platinum may open the possibility to discover novel biological targets and therefore novel modes of action.
In this Special Issue, we will focus on novel approaches to develop metal-containing drug candidates.
Prof. Dr. Elena R. Milaeva
Dr. Alexey Nazarov
Manuscript Submission Information
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- non-platinum metal-containing drugs
- biological targets
- biomolecular mode of action