Special Issue "Metabolomics in Health and Disease 2.0"
Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 3034
Interests: proteomics; metabolomics; mass spectrometry; host-pathogen interaction; tissue/organ regeneration; marine organisms; antimicrobials; echinoderms
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Metabolomics is the systematic quantification of a large part of the metabolites of a biological system (cell, tissue, organ, biological fluid, or organism) at a specific point in time. Based on the goal of the determination, metabolomics might be divided into untargeted (aiming to determine the largest part of the metabolome) or targeted (focused on the specific quantification of a selected part of the metabolome).
Mass spectrometry and nuclear magnetic resonance spectroscopy are the gold standard techniques for metabolomics. In the particular case of mass spectrometry, we can find a wealth of instrumental configurations. In addition, alternative techniques—either standalone or in combination with mass spectrometry—have also been tested for metabolomic studies. Notable examples are ion mobility spectrometry, Raman spectroscopy, infrared spectroscopy, and others.
Since metabolomics analysis generates large-scale and complex datasets, data analysis is crucial to extract biologically relevant information. Many metabolomics studies feature moderate sample counts, extremely high dimensional datasets, and complex experimental designs that require careful use of advanced statistics and machine learning.
Metabolomics is considered to provide a close link to the organism’s phenotype. Thus, alterations in the metabolome can be used as biomarkers for diagnosis, prognosis, or evolution monitoring of a wide range of diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, or rare diseases. Additionally, metabolomics can provide useful information regarding the mechanism underlying the pathological status. For all these reasons, metabolomics have become one of the most promising tools in health and disease.
This Special Issue, “Metabolomics in Health and Disease”, aims to provide a summary of the field and to explore the application of metabolomics for diagnosis, prognosis, and/or mechanism elucidation in different diseases using either human samples or animal models for disease. We warmly welcome original research and review articles dealing with these aspects.
Dr. Ana Varela Coelho
Manuscript Submission Information
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- mass spectrometry
- alternative analytical platforms for metabolomics
- data processing workflows
- computational biomarker discovery
- volatile metabolomics
- neurodegenerative diseases
- cardiovascular diseases
- rare diseases