Pharmacogenomics 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 1042
Special Issue Editor
Interests: pharmacogenomics; pharmacoepigenetics; genomics of brain disorders; neuroepigenetics; CNS drug development; neurodegenerative disorders; Alzheimer’s disease; Parkinson’s disease
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Special Issue Information
Dear Colleagues,
It is a great pleasure for me to accept the kind invitation of the International Journal of Molecular Sciences to serve as Guest Editor of a Special Issue on “Pharmacogenomics”. I think that this is a timely initiative which will be of interest to most medical disciplines. Cardiovascular disorders (25%–30%), cancer (20%–25%) and brain disorders (10%–15%) represent over 60%–70% of morbility and mortality in developed countries. Approximately 10%–20% of direct costs for disease management are attributed to pharmacological treatment, and, unfortunately, it is estimated that drug efficacy is restricted to 20%–30% of the cases treated with a particular drug in almost any medical specialty. Many different factors influence drug efficacy and safety, including the chemical properties of a drug, route of administration, disease stage, nutrition, compliance, drug–drug interactions, and pharmacogenomics.
In the coming years, the onset of a revolutionary transformation of protocols and strategies for drug development is expected. Pharmacogenomics is one of the doors through which to enter the complex building of personalized medicine.
Regulatory agencies should make recommendations to the pharmaceutical industry in favor of the introduction of pharmacogenomics in drug development and the inclusion of pharmacogenomic information on drug labels, with specific warnings for the population at risk. Educational programs are fundamental for drug prescribers to become familiar with personalized treatments. Pharmacogenetic testing should be gradually introduced into medical practice. The introduction of pharmacogenomics in routine clinical practice is fundamental for optimizing therapeutics and for reducing adverse drug reactions (ADRs), which are a major health concern worldwide. There are multiple causes of ADRs, some of which are preventable. Pharmacogenomics accounts for ≈80% of the variability in drug efficacy and safety. Over 400 genes are clinically relevant in drug metabolism, and ≈200 pharmagenes are associated with ADRs. The condition of extensive metabolizers in the Caucasian population is lower than 20%, and about 60% of patients are exposed to potential ADRs.
I would like to invite all of you, experts and beginners in the field of pharmacogeneomics, to contribute to this Special Issue with your ideas for accelerating the implementation of pharmacogenomic procedures in drug development and clinical practice.
More published papers could be found in the closed Special Issue: Pharmacogenomics and Pharmacogenomics 2.0.
Prof. Dr. Ramón Cacabelos
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacogenomics of cardiovascular disorders
- pharmacogenomics of cancer
- pharmacogenomics of brain disorders
- pharmacogenomics of metabolic and endocrine disorders
- pharmacogenomics of gastrointestinal disorders
- pharmacogenomics of lipid metabolism disorders
- pharmacoepigenomics of pain
- pharmacogenomics of psychotropic drugs
- neurodegenerative disorders (Alzheimer, Parkinson, multiple sclerosis)
