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Special Issue "Polyphenols Hazard and Safety Assessment in Human Health and Food Systems"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 197

Special Issue Editors

National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67-103, 400293 Cluj-Napoca, Romania
Interests: nanomaterials preparation and characterisation; electrochemistry; graphenes; carbon-based materials; polymers; electrochemical sensors
Special Issues, Collections and Topics in MDPI journals
National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67–103, RO, 400293 Cluj-Napoca, Romania
Interests: food and beverages authentication; traceability; metabolomics; chemometrics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Throughout the last few decades, polyphenols—plant-derived functional ingredients with different molecular structures—have become an emerging field of interest as a direct result of growing evidence suggesting their positive involvement in various health-related biological activities, through the regulation of metabolism and cell proliferation, including antioxidant, anti-inflammatory, and anticancer behavior. Besides their therapeutic effects, polyphenols’ qualities have been exploited in the food industry to boost product stability and prevent other molecules’ oxidation. This has resulted in an overestimation of the present understanding of their effects, while disregarding the fact that some polyphenol-rich foods were formerly thought to be inedible and antioxidant supplementation treatments have been linked to negative outcomes such as increased mortality or stroke. The dangers of polyphenol consumption are difficult to estimate because the bulk of risk studies have been conducted in vitro. Furthermore, the absence of established methodologies, the analysis expenses, shelf instability, and a lack of intake benchmarks make it difficult to add label content information. As a result, there is an increasing demand for trustworthy procedures that can provide a rapid and accurate response concerning polyphenol detection and quantification in food and pharmaceutical sectors, and further research is necessary to obtain full insight regarding their molecular mechanism, characterizing the short- and long-term health effects. Therefore, the intent of this Special Issue is to summarize and broaden the knowledge on polyphenol action mechanisms and development of economic and sensitive materials and analytical tools capable of supporting the control of polyphenol content and to explain their potential protective/toxic effects on the human body. We invite authors to submit both original research and review articles based on classic procedures recognized as safety control techniques, as well as the development and validation of new protocols and alternative methods that consist in the involvement of either innovative experimental setups or advanced data processing tools, such as supervised statistical methods or artificial intelligence (AI).

Dr. Lidia Magerusan
Dr. Dana Alina Magdas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • polyphenols
  • food safety
  • health risk evaluation
  • graphenes-based sensors
  • electrochemical detection
  • chemometrics
  • artificial intelligence
  • metabolomics

Published Papers

This special issue is now open for submission.
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