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Molecular Pathogenesis and Diagnostics of Lung Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 3411

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Guest Editor
1. Instituto de Investigación Sanitaria Illes Balears (IdISBa), 07120 Palma de Mallorca, Spain
2. Centro de Investigación Biomédica en Red in Respiratory Diseases (CIBERES), 28029 Madrid, Spain
Interests: COPD; miRNAs; biomarker
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Special Issue Information

Dear Colleagues,

The study of the biological pathways underlying the pathogenesis of respiratory diseases (such as COPD, lung cancer, lung fibrosis, and asthma, among others) is one of the most relevant fields for biomedical research in respiratory medicine. This Special Issue aims to focus on the most recent advances and molecular discoveries of the pathways and processes involved in lung pathogenesis, which could serve as a basis for the development of potential therapies and diagnostic tools, such as predictor biomarkers (specially microRNAs and other molecules that can be found in liquid and tissue biopsies). Original research, as well as review articles, are welcome in this Special Issue, although cutting-edge methodologies might also be considered. The spread of such advances will provide the basis and standards for further research and the development of new diagnostic and therapeutic approaches.

Dr. Amanda Iglesias
Guest Editor

Manuscript Submission Information

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Published Papers (2 papers)

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Research

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15 pages, 3242 KiB  
Article
Effect of Obstructive Sleep Apnea during Pregnancy on Fetal Development: Gene Expression Profile of Cord Blood
by Laura Cànaves-Gómez, Aarne Fleischer, Josep Muncunill-Farreny, María Paloma Gimenez, Ainhoa Álvarez Ruiz De Larrinaga, Andrés Sánchez Baron, Mercedes Codina Marcet, Mónica De-La-Peña, Daniel Morell-Garcia, José Peña Zarza, Concepción Piñas Zebrian, Susana García Fernández and Alberto Alonso
Int. J. Mol. Sci. 2024, 25(10), 5537; https://doi.org/10.3390/ijms25105537 - 19 May 2024
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Abstract
Obstructive sleep apnea (OSA) is quite prevalent during pregnancy and is associated with adverse perinatal outcomes, but its potential influence on fetal development remains unclear. This study investigated maternal OSA impact on the fetus by analyzing gene expression profiles in whole cord blood [...] Read more.
Obstructive sleep apnea (OSA) is quite prevalent during pregnancy and is associated with adverse perinatal outcomes, but its potential influence on fetal development remains unclear. This study investigated maternal OSA impact on the fetus by analyzing gene expression profiles in whole cord blood (WCB). Ten women in the third trimester of pregnancy were included, five OSA and five non-OSA cases. WCB RNA expression was analyzed by microarray technology to identify differentially expressed genes (DEGs) under OSA conditions. After data normalization, 3238 genes showed significant differential expression under OSA conditions, with 2690 upregulated genes and 548 downregulated genes. Functional enrichment was conducted using gene set enrichment analysis (GSEA) applied to Gene Ontology annotations. Key biological processes involved in OSA were identified, including response to oxidative stress and hypoxia, apoptosis, insulin response and secretion, and placental development. Moreover, DEGs were confirmed through qPCR analyses in additional WCB samples (7 with OSA and 13 without OSA). This highlighted differential expression of several genes in OSA (EGR1, PFN1 and PRKAR1A), with distinct gene expression profiles observed during rapid eye movement (REM)-OSA in pregnancy (PFN1, UBA52, EGR1, STX4, MYC, JUNB, and MAPKAP). These findings suggest that OSA, particularly during REM sleep, may negatively impact various biological processes during fetal development. Full article
(This article belongs to the Special Issue Molecular Pathogenesis and Diagnostics of Lung Diseases)
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Review

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12 pages, 3644 KiB  
Review
Vascular Endothelial Growth Factor as Molecular Target for Bronchopulmonary Dysplasia Prevention in Very Low Birth Weight Infants
by Serafina Perrone, Sara Manti, Luca Buttarelli, Chiara Petrolini, Giovanni Boscarino, Laura Filonzi, Eloisa Gitto, Susanna Maria Roberta Esposito and Francesco Nonnis Marzano
Int. J. Mol. Sci. 2023, 24(3), 2729; https://doi.org/10.3390/ijms24032729 - 1 Feb 2023
Cited by 7 | Viewed by 2505
Abstract
Bronchopulmonary dysplasia (BPD) still represents an important burden of neonatal care. The definition of the disease is currently undergoing several revisions, and, to date, BPD is actually defined by its treatment rather than diagnostic or clinic criteria. BPD is associated with many prenatal [...] Read more.
Bronchopulmonary dysplasia (BPD) still represents an important burden of neonatal care. The definition of the disease is currently undergoing several revisions, and, to date, BPD is actually defined by its treatment rather than diagnostic or clinic criteria. BPD is associated with many prenatal and postnatal risk factors, such as maternal smoking, chorioamnionitis, intrauterine growth restriction (IUGR), patent ductus arteriosus (PDA), parenteral nutrition, sepsis, and mechanical ventilation. Various experimental models have shown how these factors cause distorted alveolar and vascular growth, as well as alterations in the composition and differentiation of the mesenchymal cells of a newborn’s lungs, demonstrating a multifactorial pathogenesis of the disease. In addition, inflammation and oxidative stress are the common denominators of the mechanisms that contribute to BPD development. Vascular endothelial growth factor-A (VEGFA) constitutes the most prominent and best studied candidate for vascular development. Animal models have confirmed the important regulatory roles of epithelial-expressed VEGF in lung development and function. This educational review aims to discuss the inflammatory pathways in BPD onset for preterm newborns, focusing on the role of VEGFA and providing a summary of current and emerging evidence. Full article
(This article belongs to the Special Issue Molecular Pathogenesis and Diagnostics of Lung Diseases)
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