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Special Issue "Synthesis, Properties and Biological Evaluation of Ferrocene-Modified Peptides and Biomolecules"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 57

Special Issue Editor

Dr. Lidija Barišić
E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia
Interests: ferrocene bioconjugates; organometallic chemistry; conformational analysis; synthesis; peptidomimetics; bioactivity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The bioorganometallic chemistry of ferrocene addresses the role of ferrocene in biological systems, focusing on the design and synthesis of ferrocene-containing peptides as models for the study of protein folding, and ferrocene conjugates with biomolecules used to diagnose and combat microbial infections.

The design and development of small molecules that mimic the secondary structures of recognition domains in protein-protein interactions have been the focus of scientific research over the past 40 years. Being structurally different from natural analogs, peptide and protein mimetics are characterized by higher conformational and proteolytic stability and generally better pharmacological properties compared to natural peptides and proteins. One of the approaches for designing peptidomimetics is based on the use of small, rigid molecular scaffolds such as ferrocene, which are capable of inducing highly ordered secondary structure elements when inserted into the unordered peptides.

Ferrocene is not only easy to modify, but is also characterized by stability, redox activity, and lipophilicity, which gives its conjugates with biomolecules significant biological potential. For example, the problems of ineffectiveness of tamoxifen against estrogen-independent cancer cells and microbial resistance to chloroquine have been successfully solved by derivatization with ferrocene to obtain the ferrocifen and ferroquine, which are considered the best-known bioorganometallic compounds.

Considering the beneficial effect that ferrocene may have on the molecular properties and biological activity of its conjugates with peptides and biomolecules, you are cordially invited to contribute to this Special Issue with your work.

Dr. Lidija Barišić
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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