Special Issue "Mitochondrial Dysfunction in Aging and Diseases Affecting the Neuromuscular System"
Deadline for manuscript submissions: 31 December 2023 | Viewed by 640
Mitochondria are fundamental organelles of eukaryotic cells. In addition to being classically considered as the energy centers producing ATP for cell activities, mitochondria are involved in a large plethora of cell functions and, consequently, also in a large number of diseases. Oxidation of metabolites and ATP production, as well as calcium buffering, production of reactive oxygen species, apoptosis, and proteostasis, are among the numerous processes involving mitochondria and affecting cellular homeostasis. Mitochondrial functions are regulated in a complex manner, by controlling the number, morphology, and size of mitochondria, as well as their subcellular localization. These organelles are characterized by high plasticity, but they are also highly sensitive to aging and environmental insults that can induce mitochondrial dysfunctions and ultimately lead to disruptions of cellular homeostasis and disease. Due to their high energy requirement, neurons and skeletal myocytes are among the cell types with higher vulnerability to mitochondrial dysregulation. A large amount of experimental evidence has shown that a number of muscular and neurodegenerative diseases are characterized by alterations of mitochondrial fitness, including amyotrophic lateral sclerosis, spinal muscular atrophy, myasthenia gravis, muscular dystrophy, sarcopenia, as well as other diseases affecting the neuromuscular system, with aging-related, inflammatory, genetic or vascular origin. In this Special Issue, we would like to collect recent evidence concerning the involvement of mitochondrial physiology in the neuromuscular system, as well as studies focusing to the role of mitochondrial dysfunctions as disease mechanisms or therapeutic targets. Original articles, comprehensive reviews, systematic reviews with meta-analysis, or perspective articles are welcome.
Dr. Rosario Gulino
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- mitochondria in ALS
- mitochondria in SMA
- mitochondria in neuroinflammation
- mitochondria in muscular dystrophy
- mitochondria in sarcopenia
- mitochondria in myasthenia gravis
- mitochondria in muscle physiology
- mitochondria and motoneurons
- mitochondria and therapy