Mitochondrial Dysfunction in Aging and Diseases Affecting the Neuromuscular System
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 1163
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria are fundamental organelles of eukaryotic cells. In addition to being classically considered as the energy centers producing ATP for cell activities, mitochondria are involved in a large plethora of cell functions and, consequently, also in a large number of diseases. Oxidation of metabolites and ATP production, as well as calcium buffering, production of reactive oxygen species, apoptosis, and proteostasis, are among the numerous processes involving mitochondria and affecting cellular homeostasis. Mitochondrial functions are regulated in a complex manner, by controlling the number, morphology, and size of mitochondria, as well as their subcellular localization. These organelles are characterized by high plasticity, but they are also highly sensitive to aging and environmental insults that can induce mitochondrial dysfunctions and ultimately lead to disruptions of cellular homeostasis and disease. Due to their high energy requirement, neurons and skeletal myocytes are among the cell types with higher vulnerability to mitochondrial dysregulation. A large amount of experimental evidence has shown that a number of muscular and neurodegenerative diseases are characterized by alterations of mitochondrial fitness, including amyotrophic lateral sclerosis, spinal muscular atrophy, myasthenia gravis, muscular dystrophy, sarcopenia, as well as other diseases affecting the neuromuscular system, with aging-related, inflammatory, genetic or vascular origin. In this Special Issue, we would like to collect recent evidence concerning the involvement of mitochondrial physiology in the neuromuscular system, as well as studies focusing to the role of mitochondrial dysfunctions as disease mechanisms or therapeutic targets. Original articles, comprehensive reviews, systematic reviews with meta-analysis, or perspective articles are welcome.
Dr. Rosario Gulino
Guest Editor
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Keywords
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mitochondrial physiology
- mitochondria in ALS
- mitochondria in SMA
- mitochondria in neuroinflammation
- mitochondria in muscular dystrophy
- mitochondria in sarcopenia
- mitochondria in myasthenia gravis
- mitochondria in muscle physiology
- mitochondria and motoneurons
- mitochondria and therapy
