Adipose Tissue Dynamics in Laminopathies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1028
Lamin A, the major splicing product of the LMNA gene, is the main constituent of the nuclear lamina, a filamentous network underneath the nuclear membrane. Lamin A, in association with its nuclear envelope partners, plays a pivotal role in the organization of the nuclear architecture and in the regulation of several nuclear processes. Mutations in nuclear lamina/nuclear envelope proteins cause rare genetic diseases collectively referred to as laminopathies. Although clinically different from the other, all laminopathies present with adipose tissue dysfunction of various severities. It is becoming increasingly evident that adipose tissue dysfunction contributes to the pathogenesis of laminopathies in multiple organs. To date, neither lipodystrophy nor lipoatrophy has been improved by any of the pharmacological approaches attempted in laminopathic patients. However, many research groups are strongly committed to understanding the molecular mechanism(s) underlying LMNA-related adipose tissue loss. The aim of this Special Issue is to collect and summarize data, which can clarify the role of prelamin A in adipose tissue dynamics and pathogenetic pathways in order to provide relevant hints to refine current therapeutic strategies and suggest more efficient therapies.
Dr. Elisa Schena
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- lamin A/C
- prelamin A
- adipose tissue
- adipocyte differentiation