Special Issue "Digestive Inflammation and New Therapeutical Targets"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 7971
Interests: GPCR; signaling pathways; gastroenterology; epithelial cells; chronic inflammation; digestive cancers; apoptosis; neuropeptides; pharmacology; structure function
Chronic inflammatory gastrointestinal diseases (CIGDs) are one of the most common forms of inflammatory disease in humans. Even though CIGDs can affect any part of the gastrointestinal tract, they mainly affect the liver, the pancreas, the bile duct, the intestine/colon, as well as the stomach and esophagus. The main diseases associated with CIGDs are hepatitis, pancreatitis, cholangitis, intestinal bowel diseases (IBD), gastritis, and esophagitis. Depending on the organ involved, CIGDs have different etiologies, mechanisms, and symptoms. CIGDs have several common characteristics, including dysregulation of the immune system, imbalance of pro- and anti-inflammatory processes, disruption of the epithelium barrier function, and the involvement of microbiota or viruses. Moreover, it is now widely recognized that CIGDs represent an important risk factor in the development of cancers. Relationships between malignancies and chronic inflammation were observed for various digestive cancers, including esophagus, stomach, liver, bile duct, pancreas and colorectal cancers. Although the therapeutic arsenal for the treatment of CIGDs has developed considerably over the last decade, much remains to be done in this field.
For this Special Issue, which will be published in the International Journal of Molecular Science (IJMS), authors are welcome to submit original research articles, reviews, or shorter perspective articles dedicated to the identification of new molecular mechanisms and putative therapeutical targets in the context of CIGDs and/or the sequence CIGD cancer.
We look forward to your contributions to this Special Issue.
Dr. Alain Couvineau
Dr. Cécile Haumaitre
Manuscript Submission Information
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- digestive chronic inflammation
- epithelium barrier
- precancerous lesions