Special Issue "Roles of Lipoxygenase in Human Health and Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 88
Special Issue Editor
Interests: role of lipoxygenase in inflammatory diseases; allosteric regulation; inhibitor discovery; biological relevance
Special Issue Information
Dear Colleagues,
Lipoxygenases (LOXs) belong to the multigene family of dioxygenases containing non-heme iron in the active site of the enzyme. They catalyze the stereospecific insertion of molecular oxygen into the cis,cis-1,4-pentadiene configuration of polyunsaturated fatty acids, thus forming the corresponding hydroperoxide. Based on their positional specificity, lipoxygenases are categorized as 5-LOX, 8-LOX, 12-LOX, and 15-LOX isoenzymes, which differ not only in the position of oxidation but also in the chirality, essential for their biological activity.
LOXs, as a rate-limiting enzyme in the process of metabolizing arachidonic acid into oxylipins, such as leukotrienes (LT), exist in the human body and mediate the occurrence of inflammation. This important metabolic activity means that LOXs play an important role in a range of human diseases, such as cancer, stroke, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases. Given these implications of LOX participation in the pathogenesis of chronic inflammation diseases, considerable research in discovering novel effective inhibitors is currently underway.
Due to this emerging yet important role of LOXs, papers related to any molecular aspect of LOXs role in human health and disease will be considered for this Special Issue. For example, we will consider articles regarding novel LOX inhibitors and their mechanism, biosynthetic pathways involving LOXs, biomarkers based on LOX-derived metabolites, LOXs as therapeutic targets in various human diseases, and novel insights/future perspectives on LOX-related inflammatory diseases.
Prof. Dr. Theodore Holman
Guest Editor
Manuscript Submission Information
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Keywords
- lipoxygenase
- leukotrienes
- inflammation
- cancer
- stroke
- obesity
- diabetes, cardiovascular diseases
- neurodegenerative diseases
- inhibitors
- biosynthesis
- therapeutic targets
