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Hemoglobins: Structural, Functional and Evolutionary Characterization

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 257

Special Issue Editor

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Guest Editor
Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia
Interests: hemoglobins; nitrosative stress; carbonyl stress

Special Issue Information

Dear Colleagues,

Hemoglobins (Hb) are a remarkably widespread group of proteins. They are found in all kingdoms of life and differ in both structure and functions. First discovered in the animal kingdom, they soon were purified from legume nodules, implying that these proteins were more pervasive than previously thought. The term “phytoglobin” is now used for plant hemoglobins. After the discovery of bacterial hemoglobins, the time of their origin was pushed back by several billion years. Hemoglobins’ widespread distribution and ancient origin helped to propose the “Molecular clock” theory.

In recent years, new Hb groups have been described that are very different from the best known erythrocytic Hb, which possesses truncated, pentacoordinated characteristics. Over the past couple of decades, even with well-studied organisms, e.g., those in mammals, “new” hemoglobins have been discovered, such as neuroglobin, cytoglobin, and androglobin. The transport, catalytic, and sensory functions of these proteins have been outlined.

Hb is increasingly important for basic and applied science, implicating several areas of research.

Hemoglobins are explored under various stress conditions including oxidative, nitrosative, and carbonyl stress, and changes in their properties and functioning induced by modifications of the molecule have also been studied. Another aspect of Hb research is biotechnology. This includes Hb expression for practical purposes, as well as the studying of hemoglobins present in small quantities in their environment or the Hb of exotic organisms.

One more widely developed area is “symbiotic” hemoglobins that have specific characteristics related to their functioning in symbiotic systems. Thus, they are also used for biotechnological goals, e.g., Hb of mollusk Lucina pectinata is considered as a hydrogen sulfide scavenger, and the leghemoglobin of legume plants is gaining popularity for its application in so-called “vegetable meat”.

For this Special Issue of International Journal of Molecular Sciences, we are pleased to invite researchers to contribute original research and review articles that showcase recent developments in the structural, functional, and evolutionary characterization of hemoglobins, and demonstrate diverse applications in the process.

Dr. Alexey F. Topunov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • hemoglobin
  • phytoglobin
  • leghemoglobin
  • stress conditions
  • biotechnology

Published Papers

This special issue is now open for submission.
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