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Special Issue "Cardiac Calcium Channels in Cardiovascular Function and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 179

Special Issue Editors

Centro de Investigaciones Cardiovasculares (CONICET), Universidad Nacional de La Plata, La Plata, Argentina
Interests: signal transduction; cell culture; cell signaling; apoptosis; immunofluorescence; primary cell culture; cellular biology; signaling; cell imaging; in vitro cell culture
Centro de Investigaciones Cardiovasculares, CCT-La Plata-CONICET, Facultad de Cs. Médicas, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina
Interests: Caheart; arrhythmias; ischemia; heart failure; echocardiography; cardiac function; calcium; cardiomyopathies; cardiac electrophysiology

Special Issue Information

Dear Colleagues,

Calcium (Ca2+) signaling and the interacting networks regulate a plethora of cellular processes, such as gene expression, inflammation, synaptic transmission, induction of synaptic plasticity, excitation–contraction coupling, stimulus–secretion coupling or embryonic development.

This Special Issue will address the structure, function, and regulation of different types of Ca2+ channels in the heart as well as the consequences of their dysregulation, beginning with the L-type Ca2+ channels or dihydropyridine receptors (DHPR) at the cell membrane and the Ca release channels or ryanodine receptors (RyR2), at the sarcoplasmic reticulum (SR). These two Ca channels are main players in the process that, starting at the surface membrane level, ends inside the cell at the myofilaments level, to produce contraction, a mechanism known as excitation–contraction coupling (ECC). Alteration of this mechanism leads to cardiac arrhythmias, as well as different processes of cell death, such as apoptosis and necrosis.

In addition to these two main channels for ECC, a sophisticated system of channels and receptors is responsible for maintaining the Ca2+ concentration in cells within tight limits. This system includes the IP3 receptors, the different types of Transient Receptor Potential Canonical (TRPC) channels, as well as the Store Operated Ca channels (SOCE). This issue will also tackle these Ca2+ channels, their functional role and regulation, as well as their possible participation in different cardiac diseases.

The issue welcomes contributions that use animal, cellular, molecular and in silico approaches to shed light on pathophysiological mechanisms that involve Ca2+ channels and their impact on cardiac Ca2+ handling. Studies that have a translational perspective and contribute to closing the gap between health and disease through the modulation of Ca2+ channel function are of special interest.

Dr. Martin Vila Petroff
Prof. Dr. Alicia Mattiazzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

There is no accepted submissions to this special issue at this moment.
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