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Special Issue "New Players in the Research of Oxidative Stress and Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 December 2023 | Viewed by 2042

Special Issue Editor

Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia
Interests: oxidative stress; antioxidative defense; lipid peroxidation; reactive oxygen species (ROS); cancer; cancer stem cells; aquaporins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In spite of the huge improvement in cancer diagnostics and treatment it is still a great challenge to provide good predicitve markers and therapy to diaganose, predict the outcome and to cure the disease without recurrence. Oxidative stress is one of the factors which plays a role in bot cancer development but also as a mechanism of action against it. Therefore, it is not surprising that new players are discovered with a role in oxidative stress modulation and cancer development and progression. The issue is open to original and review papers describing new player in oxidative stress responce in cancer, as well as antioxidative defence that can be used in cancer diagnostics, prediction of the disease outcome and possible new therapeutical targets.

Dr. Ana Čipak Gašparović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • oxidative stress
  • biomarkes
  • redox signaling pathway
  • therapy resistance

Published Papers (1 paper)

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Glucose Deprivation Induces Cancer Cell Death through Failure of ROS Regulation
Int. J. Mol. Sci. 2023, 24(15), 11969; https://doi.org/10.3390/ijms241511969 - 26 Jul 2023
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In previous work, we showed that cancer cells do not depend on glycolysis for ATP production, but they do on fatty acid oxidation. However, we found some cancer cells induced cell death after glucose deprivation along with a decrease of ATP production. We [...] Read more.
In previous work, we showed that cancer cells do not depend on glycolysis for ATP production, but they do on fatty acid oxidation. However, we found some cancer cells induced cell death after glucose deprivation along with a decrease of ATP production. We investigated the different response of glucose deprivation with two types of cancer cells including glucose insensitive cancer cells (GIC) which do not change ATP levels, and glucose sensitive cancer cells (GSC) which decrease ATP production in 24 h. Glucose deprivation-induced cell death in GSC by more than twofold after 12 h and by up to tenfold after 24 h accompanied by decreased ATP production to compare to the control (cultured in glucose). Glucose deprivation decreased the levels of metabolic intermediates of the pentose phosphate pathway (PPP) and the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) in both GSC and GIC. However, glucose deprivation increased reactive oxygen species (ROS) only in GSC, suggesting that GIC have a higher tolerance for decreased NADPH than GSC. The twofold higher ratio of reduced/oxidized glutathione (GSH/GSSG) in GIS than in GSC correlates closely with the twofold lower ROS levels under glucose starvation conditions. Treatment with N-acetylcysteine (NAC) as a precursor to the biologic antioxidant glutathione restored ATP production by 70% and reversed cell death caused by glucose deprivation in GSC. The present findings suggest that glucose deprivation-induced cancer cell death is not caused by decreased ATP levels, but rather triggered by a failure of ROS regulation by the antioxidant system. Conclusion is clear that glucose deprivation-induced cell death is independent from ATP depletion-induced cell death. Full article
(This article belongs to the Special Issue New Players in the Research of Oxidative Stress and Cancer)
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