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Special Issue "Oxidative Stress and Damage Precipitated by Space-Like Conditions That Mimic Ageing: Physiological and Molecular Ground and Flight Parallels 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 November 2023 | Viewed by 151

Special Issue Editor

1. Sovaris Aerospace, Research Innovation, Infectious Disease Research Center Colorado State University, Fort Collins, CO 80521, USA
2. The National Aeronautics and Space Administration (NASA Retired) Johnson Space Center, Houston, TX 77058, USA
Interests: ageing; oxidative stress and damage; antioxidants; radiation toxicity; inflammation; genomics; proteomics; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Technological advances now allow the planning of deep space exploration missions with the aim to discover new habitats for humankind. The National Aeronautics and Space Administration (NASA) has spearheaded this effort and the research into the identification of risks to crew members associated with such lengthy missions. Exciting work from a multitude of investigators across the US, Canada, Europe, and Japan has identified oxidative damage as a key risk factor to major organs and systems physiologies that could pose a threat to the health of astronauts and the success of the mission. Through “omics technologies” and other advanced analyses, we now have defined methods to begin a comparison of human physiological responses in space flight to ground-based One Earth Normal (OEN) physiologies. This Special Issue of IJMS is dedicated to providing a comprehensive overview of the identified risks in space flight and habitation and will focus on ground-based vs. flight comparisons of how oxidative stress, when exposed to space-relevant conditions such as cosmic/galactic radiation, solar particle events, hypogravity (G-variations and partial gravity), and hypoxia/hyperoxia, or any aggregate combination of stressors, affects human physiology. Much can be learned from the examination and analysis of the parallel human physiology response and how it adapts to the hostile environment of space.

Dr. Thomas J. Goodwin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • hypoxia/hyperoxia
  • omics analyses
  • cosmic/galactic radiation
  • solar particles
  • space travel
  • Mars habitation
  • environmental stressors
  • hypogravity/gravity variations
  • oxidative stress

Published Papers

This special issue is now open for submission.
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