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Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 1723

Special Issue Editors

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Guest Editor
Division of Anatomic Pathology and Histology, Università degli Studi di Messina, Piazza Pugliatti, 1, 98122 Messina, ME, Italy
Interests: Molecular Pathology, CNS tumors, Hemopathology, Uropathology
Special Issues, Collections and Topics in MDPI journals

Guest Editor

Special Issue Information

Dear Colleagues,

Molecular testing is becoming increasingly important in thyroid pathology and is now recommended by the American Thyroid Association (ATA), National Comprehensive Cancer Network, and UpToDate. Molecular tests can help to identify malignant neoplasms within the group of cytologically indeterminate thyroid nodules. They can detect specific mutations for thyroid cancer, such as BRAF and RET/PTC, and can help to reduce the number of unnecessary diagnostic surgeries. Therefore, molecular analyses can guide appropriate treatment for thyroid nodules, providing clinically valuable diagnostic information and aiding physicians in the management of indeterminate thyroid nodules.

In this context, this Special Issue aims to cover all sectors of research based on molecular characterization of thyroid nodules. It will include original research, review articles, and short communications on molecular mechanisms implied in thyroid pathology and their potential therapeutic implications.

Dr. Maurizio Martini
Dr. Vincenzo Fiorentino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • thyroid disease
  • thyroid nodules
  • thyroid cancer
  • thyroid carcinoma
  • thyroid radiology
  • thyroid–gut axis
  • autoimmune thyroid disorders
  • thyroid hormone
  • molecular mechanisms
  • molecular tests

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Published Papers (1 paper)

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36 pages, 1254 KiB  
Do Brassica Vegetables Affect Thyroid Function?—A Comprehensive Systematic Review
by Agnieszka Galanty, Marta Grudzińska, Wojciech Paździora, Piotr Służały and Paweł Paśko
Int. J. Mol. Sci. 2024, 25(7), 3988; https://doi.org/10.3390/ijms25073988 - 3 Apr 2024
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Brassica vegetables are widely consumed all over the world, especially in North America, Asia, and Europe. They are a rich source of sulfur compounds, such as glucosinolates (GLSs) and isothiocyanates (ITCs), which provide health benefits but are also suspected of having a goitrogenic [...] Read more.
Brassica vegetables are widely consumed all over the world, especially in North America, Asia, and Europe. They are a rich source of sulfur compounds, such as glucosinolates (GLSs) and isothiocyanates (ITCs), which provide health benefits but are also suspected of having a goitrogenic effect. Adhering to PRISMA guidelines, we conducted a systematic review to assess the impact of dietary interventions on thyroid function, in terms of the potential risk for people with thyroid dysfunctions. We analyzed the results of 123 articles of in vitro, animal, and human studies, describing the impact of brassica plants and extracts on thyroid mass and histology, blood levels of TSH, T3, T4, iodine uptake, and the effect on thyroid cancer cells. We also presented the mechanisms of the goitrogenic potential of GLSs and ITCs, the limitations of the studies included, as well as further research directions. The vast majority of the results cast doubt on previous assumptions claiming that brassica plants have antithyroid effects in humans. Instead, they indicate that including brassica vegetables in the daily diet, particularly when accompanied by adequate iodine intake, poses no adverse effects on thyroid function. Full article
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