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Engineered Biomaterials for Bone Tissue Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 2534

Special Issue Editor

Department of Advanced Materials and Chemical Engineering, Daegu Catholic University, Gyeongsan 38430, Republic of Korea
Interests: biomaterials; nanofibrous membranes; bioceramics; synthesis of nanoparticles; composite materials; photodynamic therapy; cancer-targeting drugs; 3D printing; tissue regeneration
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Special Issue Information

Dear Colleagues,

The repair of bone defects originating from trauma, tumor resection, and bone diseases demands additional functional components to promote bone regeneration. The reconstruction of bone defects is a complex biological process that requires osteoconductive biomaterials, osteogenic precursor cells, and osteoinductive growth factors. Although autologous bone grafts are regarded as the gold standard for restoring bone defects, alternative materials are needed for the treatment of large-dimensional bone defects because of the limitations associated with autologous bone grafting, such as donor site morbidity, risk of rejection, and low graft availability. Therefore, functionalized biomaterials having three-dimensional (3D) structure are currently recognized as an ideal substitute for autologous bone grafts because of their biocompatibility and osteoconductivity. These biomaterials should mimic the physical and chemical properties of the extracellular matrix to promote bone regeneration, indicating that they should provide a conductive microenvironment for the selected cells. In addition, biomaterials have been demonstrated as vehicles for controlled drug (gene) delivery to repair bone defects. Many fabrication methods such as 3D printing, freeze-drying, electrospinning, double emulsion, and salt leaching methods can allow preparing porous membranes for bone tissue regeneration. The advantages of these methods can also allow successful fabrication of membranes using various types of biomaterials including polymers and their composites.

The aim of this Special Issue is to fabricate and characterize engineered biomaterials and to evaluate the biological functions of membranes for bone tissue regeneration. Topics include various fabrication methods, unique characterization, polymer and composite materials, biomedical applications such as bone tissue regeneration, drug delivery for bone defect healing, etc.

The Special Issue welcomes both original research articles and comprehensive reviews.

Prof. Dr. Young-Jin Kim
Guest Editor

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Keywords

  • 3D membrane
  • biomedical application
  • bone tissue regeneration
  • drug delivery
  • functional material
  • composite material
  • functionalization
  • fabrication

Published Papers (1 paper)

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Research

15 pages, 10973 KiB  
Article
Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration
Int. J. Mol. Sci. 2021, 22(13), 6794; https://doi.org/10.3390/ijms22136794 - 24 Jun 2021
Cited by 16 | Viewed by 2066
Abstract
The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone. This study aimed to prepare biomimetic composite scaffolds via a simple [...] Read more.
The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone. This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration. The resulting scaffolds exhibited uniform structure and homogeneous pore distribution. In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture. The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation. In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds. According to these results, biomineralization has a great influence on the biological activity of cells. Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration. Full article
(This article belongs to the Special Issue Engineered Biomaterials for Bone Tissue Regeneration)
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