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The Interplay of Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 949

Special Issue Editors

Special Issue Information

Dear Colleagues,

The field of oxidative stress and inflammation encompasses cell biology, biochemistry, chemistry, physiology and pathophysiology, extending to medicine and health and disease research as well. Oxidative stress and inflammation are closely related pathophysiological processes that can trigger one another. Both processes are found in many pathological conditions, including neurodegenerative diseases, diabetes, cardiovascular diseases, liver disease, chronic kidney disease, cancer and aging. Therefore, the screening of bio-compounds that specifically target both inflammation and oxidative stress or the concomitant use of antioxidant and anti-inflammatory agents could provide further mechanistic insight into the molecular switches controlling oxidative stress and inflammatory responses.

For this Special Issue of IJMS, we are inviting submissions in the form of an original article or review on the several molecular pathways that oxidative stress and inflammation can be affect, leading to new preventive or therapeutic approaches for the mentioned diseases.

Prof. Dr. Lorenza Speranza
Dr. Sara Franceschelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Published Papers (1 paper)

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Research

12 pages, 2423 KiB  
Article
Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure
by Irina V. Zhigacheva, Irina F. Rusina, Natalia I. Krikunova, Aleksandr N. Goloschapov, Timur L. Veprintsev, Olga I. Yablonskaya and Aleksei V. Trofimov
Int. J. Mol. Sci. 2023, 24(17), 13172; https://doi.org/10.3390/ijms241713172 - 24 Aug 2023
Viewed by 657
Abstract
The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that [...] Read more.
The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical preparations that reduce the excessive ROS generation by mitochondria should exhibit protecting properties under oxidative-stress conditions. In this context, the antioxidants resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were examined as potential chemical protectors upon the exposure to stress, able to maintain the functional state of mitochondria. Full article
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