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Special Issue "Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0"

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The Head of Nanocolloids and Disperse Systems Laboratory, Department of Physical and Quantum Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland
Interests: surfactants; disperse systems; colloids; nanoemulsions; lipid nanocarriers; polymeric nanocarriers; encapsulation/solubilization processes; colloidal stability; photodynamic therapy; theranostics
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Dear Colleagues,

Recently, many kinds of novel colloidal formulations of nanoscopic size with outstanding pharmaceutical, medical, and cosmetic potential have been investigated with an expansion in the design of a wide variety of “soft” and surface-modified nanostructures such as lipid-based or polymer-origin. For the both proposed groups of nanosystems, the rational design strategy in the self-organization of surfactants and lipids, as well as templating processes using polymers and co-polymers (including functionalized ones), should be applied, leading to the production of extremely colloidally stable, “intelligent”, and functional pharmaceutical or cosmetic forms.

This Special Issue focusses on the recent progress in the design, engineering, and physicochemical evaluation of novel nanostructured formulations and their potential in pharmaceutical, medical, and cosmetic applications. It will include research papers and review articles reflecting the most recent developments in this dynamic research area, including “soft” and surface-modified nanostructures such as lipid-based (vesicular and non-vesicular origin) and polymer-based (nanocapsules, nanomicelles, nanospheres, dendrimers, polymersomes, nanogels). Papers involving recent research and achievements in the fabrication of novel lipid–polymer and organic–inorganic nanohybrids are also welcome.

Due to the success of the 1st edition, we would like to add more results and new insights from recent research projects. You can find the 1st edition at the following link:
https://www.mdpi.com/journal/ijms/special_issues/Nanostructured_Formulations_Applications.

Dr. Urszula Bazylinska
Guest Editor

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Research

12 pages, 2529 KiB

Open AccessArticle

Tailoring Properties of Hyaluronate-Based Core–Shell Nanocapsules with Encapsulation of Mixtures of Edible Oils

Justyna Bednorz

Krzysztof Smela

and

Szczepan Zapotoczny

Int. J. Mol. Sci. 2023, 24(19), 14995; https://doi.org/10.3390/ijms241914995 - 08 Oct 2023

Viewed by 388

Abstract

Dispersions of core–shell nanocapsules (nanoemulsion) composed of liquid oil cores and polysaccharide-based shells were fabricated with emulsification using various mixtures of edible oils and amphiphilic hyaluronate derivatized with 12-carbon alkyl chains forming the shells. Such nanocapsules, with typical diameters in the 100–500 nm range, have been previously shown as promising carriers of lipophilic bioactive compounds. Here, the influence of some properties of the oil cores on the size and stability of the capsules were systematically investigated using oil binary mixtures. The results indicated that, in general, the lower the density, viscosity, and interfacial tension (IFT) between the oil and aqueous polymer solution phases, the smaller the size of the capsules. Importantly, an unexpected synergistic reduction of IFT of mixed oils was observed leading to the values below the measured for individual oils. Such a behavior may be used to tailor size but also other properties of the nanocapsules (e.g., stability, solubility of encapsulated compounds) that could not be achieved applying just a single oil. It is in high demand for applications in pharmaceutical or food industries and opens opportunities of using more complex combinations of oils with more components to achieve an even further reduction of IFT leading to even smaller nanocapsules. Full article

(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)

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20 pages, 7803 KiB

Open AccessArticle

Pharmaceutical Development of Nanostructured Vesicular Hydrogel Formulations of Rifampicin for Wound Healing

Chantal M. Wallenwein

Florian K. Groeber-Becker

Jennifer Dressman

and

Matthias G. Wacker

Int. J. Mol. Sci. 2022, 23(24), 16207; https://doi.org/10.3390/ijms232416207 - 19 Dec 2022

Cited by 3 | Viewed by 1647

Abstract

Chronic wounds exhibit elevated levels of inflammatory cytokines, resulting in the release of proteolytic enzymes which delay wound-healing processes. In recent years, rifampicin has gained significant attention in the treatment of chronic wounds due to an interesting combination of antibacterial and anti-inflammatory effects. Unfortunately, rifampicin is sensitive to hydrolysis and oxidation. As a result, no topical drug product for wound-healing applications has been approved. To address this medical need two nanostructured hydrogel formulations of rifampicin were developed. The liposomal vesicles were embedded into hydroxypropyl methylcellulose (HPMC) gel or a combination of hyaluronic acid and marine collagen. To protect rifampicin from degradation in aqueous environments, a freeze-drying method was developed. Before freeze-drying, two well-defined hydrogel preparations were obtained. After freeze-drying, the visual appearance, chemical stability, residual moisture content, and redispersion time of both preparations were within acceptable limits. However, the morphological characterization revealed an increase in the vesicle size for collagen–hyaluronic acid hydrogel. This was confirmed by subsequent release studies. Interactions of marine collagen with phosphatidylcholine were held responsible for this effect. The HPMC hydrogel formulation remained stable over 6 months of storage. Moving forward, this product fulfills all criteria to be evaluated in preclinical and clinical studies. Full article

(This article belongs to the Special Issue Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications 2.0)

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