Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 454
Special Issue Editor
Interests: cancer biomarker; evidence-based medicine; extracellular vesicles; genomics; microRNA; molecular diagnostics; non-coding RNAs; nasopharyngeal carcinoma; next-generation sequencing; non-small cell lung cancer; proteomics; drug repurposing and bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In contrast to the artificial vehicles for drug delivery in cancer, extracellular vesicle (EV) as intercellular communication has attracted tremendous interest from the scientific community for use as a vehicle for therapeutics. EVs have been studied as delivery vehicles to transport drugs, proteins, and non-coding RNA for therapeutic purposes. Various approaches are emerging, with interesting experimental results.
The efficiency and specificity of drug delivery should be considered for targeting specific cell populations in dealing with tumor heterogeneity. EVs can be engineered to deliver specific bioactive molecules to target cells. The exploitation of their molecular composition and physical properties, as well as the use of bio-techniques to modify their content, are important issues to target them to specific cells/tissues/organs.
This Special Issue particularly focuses on how EVs offer a solution to molecular cancer therapeutics, thereby providing an efficient and effective way to treat cancer that marks a paradigm shift in modern oncology.
Original papers and review articles that focus on the latest advances of EVs are welcome. Papers and review articles on but not restricted to the following key areas will be covered:
- Biology of EVs from various sources, e.g., platelet EVs, autologous cancer cell-derived EVs, etc.;
- Red blood cell EVs as RNA-based therapeutics;
- Mesenchymal stem cell-derived EVs as therapeutics and drug delivery platforms;
- Macrophage-derived exosome–mimetic hybrid vesicles for targeted drug delivery in cancer;
- Strategies in drug delivery by EVs, e.g., the modification of EV membranes;
- Cancer EVs and their association with the microenvironment, including cancer-associated fibroblasts;
- Clinical requirements for EV as a vehicle for cancer therapeutics;
- EV-based therapeutics: natural versus engineered targeting;
- EV-based therapeutics: safety and toxicity.
Dr. William Cho
Guest Editor
Manuscript Submission Information
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Keywords
- extracellular vesicle
- precision oncology
- cancer biomarker
- non-coding RNA
- molecular diagnostics
- genomics
- proteomics
