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Special Issue "The Design, Realization, Characterization, and Application of Multicomponent and Multifunctional Fibers"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 1349

Special Issue Editor

Institute for Polymers, Composites and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Interests: nanofibers; electrospinning; polymers; biobased materials; multifunctional materials

Special Issue Information

Dear Colleagues,

It is well known that different materials and morphologies can be arbitrarily used to form disparate functional fibrous structures. Polymer blending or mixing, and multilayer or multiphase morphologies, realized by combining different fabrication techniques, are effective strategies to merge the unique properties of each component (macromolecules and inorganic materials), to add or improve properties, and to create novel materials and structures. Thanks to strategies such as co-axial spinning or post-processing coating, it is also possible to produce fibers based on materials with completely different properties or on not spinnable materials. Multicomponent and multifunctional fibers have enhanced properties and are able to better fulfill the application requirements in biomedical, healthcare, environmental field, and so on; furthermore, they can be able to mimic the complex environment where they are applied.

Contributions to this Special Issue will provide further advancements in the design, realization and characterization of multicomponent and multifunctional fibers; they will highlight the current and future research needs in order to improve and broaden multicomponent and multifunctional fibers applications and commercialization.

Dr. Irene Bonadies
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • composite fibers
  • functional fibers
  • blends
  • nanocomposites
  • nanostructured fibers
  • electrospinning
  • fiber coatings

Published Papers (1 paper)

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18 pages, 13369 KiB  
Improving Solubility and Permeability of Hesperidin through Electrospun Orange-Peel-Extract-Loaded Nanofibers
Int. J. Mol. Sci. 2023, 24(9), 7963; https://doi.org/10.3390/ijms24097963 - 27 Apr 2023
Cited by 2 | Viewed by 1100
Orange peel, which is a rich source of polyphenolic compounds, including hesperidin, is produced as waste in production. Therefore, optimization of the extraction of hesperidin was performed to obtain its highest content. The influence of process parameters such as the kind of extraction [...] Read more.
Orange peel, which is a rich source of polyphenolic compounds, including hesperidin, is produced as waste in production. Therefore, optimization of the extraction of hesperidin was performed to obtain its highest content. The influence of process parameters such as the kind of extraction mixture, its temperature and the number of repetitions of the cycles on hesperidin content, the total content of phenolic compounds and antioxidant (DPPH scavenging assay) as well as anti-inflammation activities (inhibition of hyaluronidase activity) was checked. Methanol and temperature were key parameters determining the efficiency of extraction in terms of the possibility of extracting compounds with the highest biological activity. The optimal parameters of the orange peel extraction process were 70% of methanol in the extraction mixture, a temperature of 70 °C and 4 cycles per 20 min. The second part of the work focuses on developing electrospinning technology to synthesize nanofibers of polyvinylpyrrolidone (PVP) and hydroxypropyl-β-cyclodextrin (HPβCD) loaded with hesperidin-rich orange peel extract. This is a response to the circumvention of restrictions in the use of hesperidin due to its poor bioavailability resulting from low solubility and permeability. Dissolution studies showed improved hesperidin solubility (over eight-fold), while the PAMPA-GIT assay confirmed significantly better transmucosal penetration (over nine-fold). A DPPH scavenging assay of antioxidant activity as well as inhibition of hyaluronidase to express anti-inflammation activity was established for hesperidin in prepared electrospun nanofibers, especially those based on HPβCD and PVP. Thus, hesperidin-rich orange peel nanofibers may have potential buccal applications to induce improved systemic effects with pro-health biological activity. Full article
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