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Epigenetic Mechanisms of Cardiac Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 134

Special Issue Editor

1. Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
2. ICMC (Integrated Cardio Metabolic Centre), Myocardial Genetics, Karolinska Institutet, University Hospital, Dept. of Medicine, Heart and Vascular Theme, Novum, Hiss A, Våning 7, Hälsovägen 7-9, 141 57 Huddinge, Sweden
Interests: genetics; heart failure; epigenetics; molecular mechanisms
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Special Issue Information

Dear Colleagues,

Despite major breakthroughs in molecular biology and significant improvements in clinical medicine, heart failure remains a major cause of death worldwide. Our understanding of heart failure remains incomplete, despite that fact that a genetic basis can be identified in 30%–50% of individuals with heart failure and fundamental molecular mechanisms including hypertrophic signaling and a calcium metabolism have been unraveled.

In this context, recent successful clinical trials point to the importance of sophisticated exploitation of already-known signal transduction pathways, inflammation, and the need to explore even more novel biology and take interdisciplinary approaches to improve patients’ lives, for example, through SGLT2 inhibitors and diabeto-cardiology.

Along these lines and apart from genetics, epigenetics (“epi-” means above in Greek)—which is defined as inheritable DNA modifications that do not change the DNA sequence but which can affect gene activity—might play a role. These changes can be direct, for example, via genomic DNA methylations, or indirect, via DNA interacting molecules such as histones or via miRNAs or similar.

In summary, genetic and epigenetic mechanisms are likely to operate in heart failure, the unraveling of which will undoubtedly lead to an improvement in patients’ lives.

In this issue, we will collate a wide variety of papers looking at different aspects of epigenetic mechanisms underlying heart failure.

Dr. Ralph Knoll
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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