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Special Issue "The Tight Junction and Its Proteins: From Structure to Pathologies"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 521

Special Issue Editors

Institute of Clinical Physiology/Nutritional Medicine, Charité—Universitätsmedizin Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany
Interests: tight junctions and their proteins: claudin family, TAMP family, angulin family; functional properties: barriers and ion channels, water channels, claudin- and TAMP-mediated water transport, claudins of the kidney, tricellular tight junction; mechanisms: macromolecule permeation, drug absorption enhancers
Special Issues, Collections and Topics in MDPI journals
Institute of Clinical Physiology/Nutritional Medicine, Charité–Universitätsmedizin Berlin, Berlin, Germany
Interests: tricellulin: function, regulation, structure, and clinical impact; the interplay of the impaired tight junction and the subjacent immune cells in inflammation; the role of the tricellular tight junction in inflammatory bowel diseases; inflammatory bowel diseases: barrier defect via IL-13 and tricellulin; tricellular tight junction as a pathway for macromolecules; drug absorption enhancement by targeting the tricellular TJ; neuropathic pain resolution by nerve barrier sealing and netrin-1
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Most tight junction (TJ) proteins build epithelial and endothelial barriers. Some, however, form paracellular ion or water channels. Besides barrier and channel properties, numerous other functions gain increasing interest: TJ proteins can serve as receptors for pathogens and mediate immunological reactions. They are involved in several inflammatory diseases and bacterial infections. In cancer, they can mediate epithelial–mesenchymal transition, facilitating tumorigenesis and metastasis. They also serve as targets in tumor diagnostics and treatment.

This Special Issue (SI) is a continuation of our SI from 2020, "The Tight Junction and Its Proteins: More Than Just a Barrier", which included 44 articles.

The current SI is subtitled ".... From Structure to Pathologies" in order to give credit to recent research progress on the molecular structure of TJ proteins, as well as on TJ-related pathologies. Original or review articles within the full spectrum of molecular TJ research are welcome.

Prof. Dr. Michael Fromm
Dr. Susanne M. Krug
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • epithelial and endothelial barrier
  • claudin channel proteins
  • bi- and tricellular tight junction
  • claudins and cancer
  • inflammation and infection
  • molecular structure and assembly
  • cell and tissue differentiation and development

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Published Papers

This special issue is now open for submission.
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