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Gastrointestinal: Inflammation, Immunity and Cancer Pathways

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 2665

Special Issue Editor

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Guest Editor
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Interests: inflammation and cancer biology; immunology and bacterial pathogenesis; mitochondrial metabolism; post-translational modification; dietary agents; drug discovery; protein structure biology; life-style and environmental cancer; risk factors
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Special Issue Information

Dear Colleagues,

Cancer’s risk appears to evolve over time as a possible result of changes in dietary, environmental and lifestyle factors, including infection, diet, drug abuse, radiations, and stress; however, the etiology of cancer is complex, comprising infectious agent genomic variability, host genetic and environmental are the strongest risk factor for the development of carcinoma. Cancer is a major problem of disease worldwide and each year, more than millions of people are detected with cancer around the world, and more than half of them die. Gastrointestinal cancers are among the highest death causing cancers in the world. The incidence of these cancers were an estimated 4.8 million cases and 3.4 million deaths worldwide. Gastrointestinal cancer is a group of cancers that affect the gastrointestinal tract. Gastrointestinal cancer include esophageal, stomach, gallbladder, gastrointestinal stromal tumor, liver, pancreatic, colon, rectal and anal cancer.

Through this Special Issue “Gastrointestinal: Inflammation, Immunity and Cancer Pathways” we aim to highlight the new discoveries and advances in the mechanism, diagnosis, prevention, and treatment in gastrointestinal cancer molecular biology.

Dr. Faisal Aziz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • inflammation and cancer biology
  • infectious agents
  • post-translational modification
  • signaling pathway
  • apoptosis
  • autophagy
  • necrosis
  • necroptosis
  • innate immunity
  • host–pathogens interactions
  • cell proliferation
  • tumor microenvironment

Published Papers (1 paper)

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14 pages, 3232 KiB  
Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo
by Haibo Zhang, Lei Ma, Eungyung Kim, Junkoo Yi, Hai Huang, Hyeonjin Kim, Muhammad Atif Raza, Sijun Park, Soyoung Jang, Kirim Kim, Sung-Hyun Kim, Youngkyun Lee, Eunkyong Kim, Zae Young Ryoo and Myoung Ok Kim
Int. J. Mol. Sci. 2023, 24(10), 8507; https://doi.org/10.3390/ijms24108507 - 9 May 2023
Cited by 4 | Viewed by 2175
Oral cancer remains the leading cause of death worldwide. Rhein is a natural compound extracted from the traditional Chinese herbal medicine rhubarb, which has demonstrated therapeutic effects in various cancers. However, the specific effects of rhein on oral cancer are still unclear. This [...] Read more.
Oral cancer remains the leading cause of death worldwide. Rhein is a natural compound extracted from the traditional Chinese herbal medicine rhubarb, which has demonstrated therapeutic effects in various cancers. However, the specific effects of rhein on oral cancer are still unclear. This study aimed to investigate the potential anticancer activity and underlying mechanisms of rhein in oral cancer cells. The antigrowth effect of rhein in oral cancer cells was estimated by cell proliferation, soft agar colony formation, migration, and invasion assay. The cell cycle and apoptosis were detected by flow cytometry. The underlying mechanism of rhein in oral cancer cells was explored by immunoblotting. The in vivo anticancer effect was evaluated by oral cancer xenografts. Rhein significantly inhibited oral cancer cell growth by inducing apoptosis and S-phase cell cycle arrest. Rhein inhibited oral cancer cell migration and invasion through the regulation of epithelial–mesenchymal transition-related proteins. Rhein induced reactive oxygen species (ROS) accumulation in oral cancer cells to inhibit the AKT/mTOR signaling pathway. Rhein exerted anticancer activity in vitro and in vivo by inducing oral cancer cell apoptosis and ROS via the AKT/mTOR signaling pathway in oral cancer. Rhein is a potential therapeutic drug for oral cancer treatment. Full article
(This article belongs to the Special Issue Gastrointestinal: Inflammation, Immunity and Cancer Pathways)
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