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Special Issue "Recent Advances in Photolysis and Photodegradation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 898

Special Issue Editor

1. Faculty of Physics, St. Peterburg State University, 199034 St. Petersburg, Russia
2. Institute of Physics, Kazan Federal University, 420008 Kazan, Russia
Interests: photochemistry; molecur biophysics; photosensitization; pterins; aromatic amino acids; metal nanoclusters; density functional theory; QSAR/QSPR

Special Issue Information

Dear Colleagues,

Photolysis is a chemical process that occurs when molecules absorb photons and degrade into smaller units. This Special Issue aims to cover the photodissociation/photofragmention topic for biomolecular and non-biomolecular systems. A particular example of such a bioprocess is the photolysis of water during photosynthesis, the biophotolysis production of hydogen, etc. Another important point is the photosensitized degradation of chemical substances which do not absorb light themselves, but become subjected to photolytic degradation. Photodegradation is a process associated with the turnover of colored photolabile compounds in ecosystems. For this reason, the photodegradation of chemical compounds and its effect on the environment are explored in this Special Issue, particularly the photodegrdation of drug substances and their negative effect on organism. The process of photolysis is not restricted to visible light only, but may occur under ultraviolet and X-ray radiation, as well as infrared multiphoton irradiation. Both theoretical and experimental studies are welcomed to be published in the Special Issue.

Dr. Andrey А. Buglak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • indirect photolysis
  • photosensitized oxidation
  • biophotolysis
  • photodissociation
  • photofragmentation
  • ultraviolet radiation
  • photoactive drugs

Published Papers (1 paper)

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18 pages, 2691 KiB  
Tetrahydrobiopterin as a Trigger for Vitiligo: Phototransformation during UV Irradiation
Int. J. Mol. Sci. 2023, 24(17), 13586; https://doi.org/10.3390/ijms241713586 - 01 Sep 2023
Viewed by 642
Vitiligo is a type of hypomelanosis. Tetrahydrobiopterin (H4Bip), the coenzyme of the initial stage of melanogenesis, appears to be a trigger for vitiligo. H4Bip is present in vitiligo in 3–5-fold excess and causes oxidative stress by triggering an autocatalytic [...] Read more.
Vitiligo is a type of hypomelanosis. Tetrahydrobiopterin (H4Bip), the coenzyme of the initial stage of melanogenesis, appears to be a trigger for vitiligo. H4Bip is present in vitiligo in 3–5-fold excess and causes oxidative stress by triggering an autocatalytic cycle of excess hydrogen peroxide synthesis. Using quantum-chemical calculations, we have evaluated the possibility of H4Bip reactions occurring in the dark and under ultraviolet (UV) irradiation, including the formation of dihydropterin dimers. In order to simulate the oxidative stress, oxidative modification of human serum albumin (HSA) has been carried out in the presence of excessive H4Bip using the fluorescence method. The fraction of oxidized protein (FOP) has been calculated. It has been established that there is a strong oxidative modification of amino acids chromophores (tryptophan and tyrosine) in the protein (FOP 0.64). Under UV irradiation of the system (HSA + H4Bip), FOP is reduced to 0.39. Apparently, a part of H4Bip transforms into dihydropterin dimers and does not participate in the oxidative modification of the protein. The data on oxidative modification of HSA are consistent with dynamic light scattering: H4Bip promotes HSA aggregation with the formation of particles with a hydrodynamic radius Rh ≥ 2000 nm, which can become immunogenic. Full article
(This article belongs to the Special Issue Recent Advances in Photolysis and Photodegradation)
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