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Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 144

Special Issue Editor

E-Mail Website
Guest Editor
1. Department of Animal Science, Iowa State University, Ames, IA, USA
2. Division of Animal Sciences, University of Missouri-Columbia, Columbia, MO, USA
Interests: male infertility; sperm capacitation; sperm diagnostics; high-throughput single cell phenomics

Special Issue Information

Dear Colleagues,

Sperm development is a multifaceted biological process characterized by a series of interconnected stages, beginning with germ cell proliferation and differentiation in the testes, continuing through the maturation in the male reproductive tract, and culminating in the achievement of fertilization potential. This intricate journey is marked by significant biochemical and morphological transformations, essential for the acquisition of fertility. Advanced research delving into the intricacies of sperm cell metabolism, seminal fluid biochemical composition, and the multifarious steps of sperm capacitation including steps thereafter to penetrate and activate the oocyte have been instrumental in deepening our understanding of male reproductive biology. These insights are pivotal in elucidating the complex molecular interplay underpinning male fertility.

This special issue is titled “Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development” and aims to collect original articles and reviews, focusing on key molecular mechanisms in sperm development and covering the latest discoveries in sperm cell metabolism. This special issue is dedicated to the exploration of spermatogenesis, epididymal maturation, sperm capacitation, and the steps that ultimately support oocyte activation, with a special focus on the molecular mechanisms behind them. This special issue aims to provide theoretical support for in vitro and in vivo studies of animal reproduction.

Dr. Karl Kerns
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • sperm development 
  • germ cell proliferation 
  • sperm cell metabolism 
  • seminal fluid biochemical composition 
  • spermatogenesis 
  • epididymal maturation 
  • sperm capacitation 
  • oocyte activation

Published Papers

This special issue is now open for submission.
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