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Novel Tobacco Exposure and Health Effects

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A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 17416

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Dr. Cindy M. Chang

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Guest Editor

Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA
Interests: cigarettes; e-cigarettes; smokeless tobacco; health effects; biomarkers

Special Issue Information

Dear Colleagues,

Novel tobacco products including e-cigarettes, heated tobacco products, and nicotine pouches are rapidly emerging in the tobacco landscape and could potentially help smokers move away from cigarettes. Additional research can help strengthen our understanding as to whether these novel tobacco products, as actually used, result in a benefit to population health. For example, to what extent are smokers willing to switch to these products, and what user and product characteristics are associated with switching? What are the changes, if any, in health measures as a result of complete switching or a substantial reduction in smoking? What are some potential health risks associated with use of the product as compared with cigarettes, other categories of novel tobacco products, and no use? Are there health effects due to secondhand exposure to these novel tobacco products? This Special Issue of the International Journal of Environmental Research and Public Health titled “Novel Tobacco Exposure and Health Effects” offers an opportunity to publish high-quality population health research. We are particularly interested in research related to observational studies of tobacco use behavior related to novel tobacco product use as well as the impact on health risk as measured using biomarkers and short- and long-term health outcomes. All manuscripts will be peer reviewed by experts in the field and will be due 30 June 2023. The Guest Editor of this Special Issue is Cindy M. Chang, PhD, MPH (Center for Tobacco Products, Food and Drug Administration).

Disclaimer: This presentation is not a formal dissemination of information by FDA and does not represent Agency position or policy. We will not accept research funded in part or full by any tobacco companies in this Special Issue. For more details, please check: https://www.mdpi.com/1660-4601/15/12/2831/htm.

Dr. Cindy M. Chang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

observational studies
e-cigarettes
heated tobacco products
nicotine pouches
health effects
biomarkers
switching

Published Papers (5 papers)

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12 pages, 349 KiB

Open AccessArticle

Nicotine Pouch: Awareness, Beliefs, Use, and Susceptibility among Current Tobacco Users in the United States, 2021

by Lindsey S. Sparrock, Lilianna Phan, Julia Chen-Sankey, Kiana Hacker, Aniruddh Ajith, Bambi Jewett and Kelvin Choi

Int. J. Environ. Res. Public Health 2023, 20(3), 2050; https://doi.org/10.3390/ijerph20032050 - 22 Jan 2023

Cited by 3 | Viewed by 3049

Abstract

Little is known about awareness, beliefs, and use of nicotine pouches (NPs). Data from 1583 U.S. adult (age ≥ 21 years) current tobacco users were collected in 2021. Respondents self-reported NP awareness, beliefs, use, and susceptibility as well as current tobacco product use and socio-demographics. We used weighted logistic and multinomial regression models to explore the associations between these variables. Overall, 46.6% of U.S. adult current tobacco users were aware of, 16.4% had ever used, and 3.0% currently used NPs. Younger individuals (vs. 61+ years) were more likely to have ever heard of NPs, while Black individuals (vs. White) were less likely to have ever heard of NPs. Individuals younger than 45 years (vs. 61+ years) and those using smokeless tobacco products (vs. non-users) were more likely to have ever used NPs. Additionally, younger than 45 years (vs. 61+ years) and current use of certain tobacco products (e.g., smokeless) were associated with current NP use. Holding favorable beliefs about NPs was associated with susceptibility to and more advanced NP use statuses (p < 0.05). Continuous surveillance of NP use and beliefs is important. Full article

(This article belongs to the Special Issue Novel Tobacco Exposure and Health Effects)

11 pages, 348 KiB

Open AccessArticle

Heated Tobacco Products: Awareness, Beliefs, Use and Susceptibility among US Adult Current Tobacco Users, 2021

by Lindsey S. Sparrock, Lilianna Phan, Julia Chen-Sankey, Kiana Hacker, Aniruddh Ajith, Bambi Jewett and Kelvin Choi

Int. J. Environ. Res. Public Health 2023, 20(3), 2016; https://doi.org/10.3390/ijerph20032016 - 21 Jan 2023

Cited by 2 | Viewed by 1724

Abstract

Limited data exist on the awareness, beliefs, and use of heated tobacco products (HTPs). Data from 1583 U.S. adult (age ≥ 21 years) current tobacco users were collected in 2021. Participants self-reported HTP awareness, beliefs, use, and susceptibility, as well as current tobacco product use and sociodemographics. We used weighted logistic and multinomial regression models to explore their associations. Overall, 23.6% were aware of, 8.9% had ever used, and 3.0% currently used HTPs. Younger individuals (vs. 61+ years), those with annual income $50,000+ (vs. <$50,000), and those currently using electronic vaping products (vs. non-users) were more likely to be aware of, to have ever used, and to currently be using HTPs (p < 0.05). Black individuals (vs. White) were more likely to report ever and current HTP use (p < 0.05). Current cigarette smoking was not associated with HTP awareness and use (p > 0.05). Holding favorable HTP beliefs was associated with susceptibility to and more advanced HTP use statuses (p < 0.05). Sociodemographics associated with HTP use may reflect HTP marketing strategies. The lack of association with cigarette smoking suggests HTPs may be unlikely cigarette substitutes. Addressing favorable HTP-related beliefs may prevent dual use. Full article

(This article belongs to the Special Issue Novel Tobacco Exposure and Health Effects)

8 pages, 331 KiB

Open AccessArticle

Influence of Electronic Cigarettes on Selected Physicochemical Properties of Saliva

by Dominika Cichońska, Aida Kusiak, Barbara Kochańska, Jolanta Ochocińska and Dariusz Świetlik

Int. J. Environ. Res. Public Health 2022, 19(6), 3314; https://doi.org/10.3390/ijerph19063314 - 11 Mar 2022

Cited by 7 | Viewed by 2082

Abstract

(1) Background: Electronic cigarettes are gaining more popularity not only among cigarettes smokers. Firstly, e-cigarettes were perceived as less harmful than traditional cigarettes, however, nowadays, they are arousing more controversy. The aim of this study was to assess the impact of e-cigarette usage on selected physicochemical properties of saliva. (2) Methods: The study population included 128 patients: 40 patients using e-cigarettes, 39 patients smoking traditional cigarettes, and 49 non-smoking patients (non-smokers). Laboratory tests involved verification of saliva values of pH and concentration of total protein, calcium, and phosphates. (3) Results: Among e-cigarette users, the value of pH was lower and the concentration of total protein, calcium, and phosphates was higher than in the group of non-smokers. Statistically significant differences were observed in relation to calcium. Among traditional cigarette smokers, the value of pH was lower, concentrations of total protein and phosphates were higher than in the group of non-smokers. Statistically significant differences were observed in relation to total protein. (4) Conclusions: Saliva of e-cigarette users presents changes in physicochemical composition in comparison to traditional cigarette smokers and non-smokers, however, statistically significant differences were observed only in calcium concentration. Further longitudinal studies on a larger study group should be conducted to assess the effect of observed changes in oral health. Full article

(This article belongs to the Special Issue Novel Tobacco Exposure and Health Effects)

13 pages, 1107 KiB

Open AccessArticle

Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015

by Gabriella M. Anic, Brian L. Rostron, Hoda T. Hammad, Dana M. van Bemmel, Arseima Y. Del Valle-Pinero, Carol H. Christensen, Gladys Erives, Lisa M. Faulcon, Benjamin C. Blount, Yuesong Wang, Lanqing Wang, Deepak Bhandari, Antonia M. Calafat, Heather L. Kimmel, Colm D. Everard, Wilson M. Compton, Kathryn C. Edwards, Maciej L. Goniewicz, Binnian Wei, Andrew Hyland, Dorothy K. Hatsukami, Stephen S. Hecht, Raymond S. Niaura, Nicolette Borek, Bridget K. Ambrose and Cindy M. Chang Show full author list Hide full author list

Int. J. Environ. Res. Public Health 2022, 19(3), 1462; https://doi.org/10.3390/ijerph19031462 - 27 Jan 2022

Cited by 12 | Viewed by 6545

Abstract

Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC) and metals, changed when 2475 adult smokers transitioned to using ENDS or quit tobacco products. Exclusive smokers who transitioned to dual use had a significant decrease in NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most PAHs, metals, or VOCs. Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, NNAL, and 2CyEMA (acrylonitrile metabolite), but only in those who reduced cigarettes per day (CPD) by >=50%. Smokers who transitioned to exclusive ENDS use had significant reductions in most TSNAs, PAHs, and VOCs; however, nicotine metabolites did not decrease in dual users who became exclusive ENDS users. Smokers who quit tobacco use had significant decreases in nicotine metabolites, all TSNAs, most PAHs, and most VOCs. Cigarette smokers who became dual users did not experience significant reductions in most BOEs. Reductions were impacted by changes in CPD. However, transitioning from smoking to no tobacco or exclusive ENDS use was associated with reduced exposure to most BOEs measured. Future analyses could incorporate additional waves of PATH data and examine changes in biomarker exposure by ENDS device type and CPD. Full article

(This article belongs to the Special Issue Novel Tobacco Exposure and Health Effects)

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23 pages, 1547 KiB

Open AccessSystematic Review

The Health Effects of Real-World Dual Use of Electronic and Conventional Cigarettes versus the Health Effects of Exclusive Smoking of Conventional Cigarettes: A Systematic Review

by Charlotta Pisinger and Sofie K. Bergman Rasmussen

Int. J. Environ. Res. Public Health 2022, 19(20), 13687; https://doi.org/10.3390/ijerph192013687 - 21 Oct 2022

Cited by 7 | Viewed by 3194

Abstract

Background: A high prevalence of dual use of e-cigarettes and conventional cigarettes has been reported across the world. Methods: A systematic search was carried out. We included original articles on any topic relevant to health, excluding mental health, in all languages. The PRISMA guidelines were followed. Both reviewers independently screened and read all publications. We compared dual use with exclusive smoking of conventional cigarettes (ESCC). Results: Fifty-two publications (49 studies) were included. Thirteen papers/10 studies were prospective. There was great heterogeneity across studies. Many methodological weaknesses, such as inaccurate exposure measurement, lack of adjustment for former tobacco consumption, and lack of significance testing were identified. Most prospective studies found dual use to be at least as harmful as ESCC. The longest follow-up was six years. Most of the best available cross-sectional studies found dual use associated with the same and, in several studies, significantly higher risk of self-reported symptoms/disease than in ESCC. The intensity of cigarette smoking seems associated with worse health. Conclusion: Existing studies indicate that dual use is at least as, or probably even more, harmful than ESCC. Due to the predominance of cross-sectional studies and the methodological weaknesses we judged the overall certainty of the evidence as “low certainty”. Full article

(This article belongs to the Special Issue Novel Tobacco Exposure and Health Effects)

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